25.2. Mechanisms of Drug Interactions Flashcards

1
Q

Pharmaceutical /pharmacokinetic/pharmacodynamic interactions

A
  • Diazapam
  • Thiopentone
  • Naloxone
  • Propronolol
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2
Q

Distribution and clearance

A

*Warfarin
*Phenytoin
*Aspirin
*Probenecid
*Methotrexate
Metoclopramide
Calcium

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3
Q

Albumin/P450 inhibition/induction

A

*Warfarin
*Cimetidine
*Phenobarbitone
*Grapefruit juice
Isoniazid
Ketoconazole

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4
Q

Acute and chronic differences

A
  • Phenytoin

* Rifampicin

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5
Q

Drugs with narrow therapeutic indexes

A
  • Digoxin
  • Warfarin
  • Lithium
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