SRY gene Flashcards
1
Q
SRY
A
Requires to develop testes, which then develop
Sertoli cells and Leydig cells
2
Q
Sertoli cells
A
Produces MIF, which degenerates Paramesonephric (Mullerian duct, female internal genitalia)
3
Q
No sertoli cells or MIF
A
Develop both male and female internal genitalia
Male external genitalia
4
Q
Leydig cells
A
Produces testosterone, which converts mesonephric (Wolffian) to male internal genitalia (except prostate)
Testosterone gets converted to DHT by 5alpha reductase peripherally
5
Q
DHT
A
Converts genital tubercle and urogenital sinus to
male external genitalia and prostate
6
Q
5alpha-reductase deficiency
A
Male internal genitalia,
Ambiguous external genitalia until puberty.
