Iron Surose Flashcards
What is iron surose?
another form of parenterally administered iron for iron-deficient anaemia
What class of drugs does iron sucrose belong to?
antianaemic agent
what are other drugs in the same class as iron sucrose?
iron polymaltose
ascorbic acid injection
What is the dose of iron sucrose given for iron deficiency anaemia?
this is calculated aroding to bodyweight and deficit
What is the menchanism of action of iron sucrose?
Iron sucrose dissociates into iron and sucrose via reticulondothelial system. The iron is transferred from the blood to a pool of iron in the liver and bone marrow.
Ferritin (iron storage protein) binds and sequesters iron in the anontoxic form. Iron then binds to transferrin which carries it within the plasma and the ECF to supply the tissues.
Transferrin receptor bdins the transferrin iron complex which is then internalised in vesicles. Iron is released within the cell.
What are the main PK and PD parameters associated with Iron sucrose?
Stable complex which does not release ioni iron under physiological conditions.
PK:
volume of distribution ~3L
Terminal half life ~6hours
Renal elimination which occurs in the first 4 hours after injection corresponds to <5% of total body clearance.
What are the precautions associated with iron sucrose use?
do not give until 5 days after last injection
infection
patient with history of immune/inflammatory conditions
liver dysfunction
What are the contraindications associated with iron sucrose use?
during the 1st trimester of pregnancy
anaemia not caused by iron-deficiency
iron overload/disturbances in utilisation of iron
konwn hypersensitivity to iron sucrose or any of its inactive components
What are the adverse reactions associated with Iron sucrose use?
taste disturbances
less common: nausea, vomiting, abdominal pain, diarrhoea, hypotension, tachycardia, flushing, palpitation, chest pain, bronchospasm, dyspnoea, headache, dizziness, fever, myalgia, pruititis, rash, injection site reactions
What are the drug interactions associated with iron sucrose use?
Antacids: absorption of oral iron reduced
calcium salts: absorption of oral iron is reduced
antibacterials: oral iron reduces the absorption
bisphosphonates: oral iron reduces the absorption
thyroid hormones: oral iron reduces the absorption
Zinc: both zinc and oral iron absorption is reduced.
What are the alarm bells associated with iron sucrose use?
patients with history of allergy disorders (asthma, eczema, other atopic conditions, or a history of immune/inflammatory conditions are more prone to hypersensitivity reactions
What monitoring is involved with iron sucrose use?
monitor patient during, and for 30-60 minutes after every infusion.
facilities for CPR should be available.
