26.4 - Carboxylic acid derivatives Flashcards Preview

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Flashcards in 26.4 - Carboxylic acid derivatives Deck (24):
1

List 4 carboxylic acid derivatives

Ester
Acyl chloride
Acid anhydride
Amide

2

What is an esterification (condensation) reaction?

A reaction in which a carboxylic acid reacts with an alcohol to form an ester and water

3

What conditions are needed for an esterification reaction?

The alcohol is warmed with concentrated sulphuric acid

4

What are the products of an esterification reaction between propanoic acid + ethanol?

Ethyl propanoate + water

5

Esters can be hydrolysed by: 1? + 2?

1) Acid (aq)
2) Alkali (aq)

6

Define hydrolysis

The chemical breakdown of a compound in the presence of water or in aq solution.

7

What are the products of acid hydrolysis? (ester + water)

Carboxylic acid + alcohol

8

What conditions are needed for acid hydrolysis?

Heat under reflux with dilute aq acid

9

What are the products of alkaline hydrolysis?

Carboxylate salt + alcohol

10

What conditions are needed for alkaline hydrolysis?

Heated under reflux with aq hydroxide ions

11

What are the products of this alkaline hydrolysis reaction?
methyl ethanoate + NaOH --> ? + ?

Sodium ethanoate + methanol

12

How do you prepare acyl chlorides?

React carboxylic acid with SOCl2

13

What condition is needed for the preparation of acyl chlorides?

Fume cupboard

14

Write an equation for the preparation of propanoyl chloride

propanoic acid + SOCl2 --> propanoyl chloride + SO2 + HCl

15

Acyl chloride + alcohol --> ? + ?

Ester + HCl

16

Acyl chloride + phenol --> ? + ?

Ester + HCl

17

Acyl chloride + H2O --> ? + ?

Carboxylic acid + HCl

18

What observation would take place when reacting acyl chlorides with water to form carboxylic acids?

Dense, steamy HCl fumes

19

What is formed when acyl chlorides are reacted with ammonia/amines?

Amides

20

Do ammonia and amines act as electrophiles or nucleophiles?

Nucleophiles

21

Products of acyl chlorides + ammonia?

Primary amide + ammonium chloride

22

Products of acyl chlorides + primary amines?

Secondary amide + other product

23

Which is more reactive; acyl chlorides or acid anhydrides?

Acyl chlorides

24

Ethanoic anhydride + phenol --> ? + ?

Phenyl ethanoate + ethanoic acid