Toxicology

Question 0

Carbon disulfide has been associated with?

Answer 0

A. Elevated cholesterol levels and early atherosclerosis
B. peripheral neuropathy (chronic)
C. Encephalopathy & psychosis (acute)
D. Optic neuritis

Question 1

Biological monitoring for benzene is accomplished by?

Answer 1

Using total urinary phenols for acute overexposure, and complete blood count with differential for compliance with mandated monitoring

Question 2

Biological half-life of carb oxyhemoglobin is?

Answer 2

4 hrs.

Or 60-90 min with 100%oxygen via face mask.

Question 3

Which of the following Metals that is implicated in asthma,in the aggressive fibrosing lung disorder, hard metal disease, and has been associated with cardiomyopathy in beer drinkers?
A. Cobalt
B. copper
C. Chromium
D. Platinum

Answer 3

A

Question 4

Health effect of ethylene oxide exposure?

Answer 4

A. Mucous membrane & skin irritant
B. Toxic encephalopathy
C. Mixed motor-sensory peripheral neuropathy
D. Nausea & vomiting

Question 5

At what level of expose of hydrogen sulfide will olfactory nerve paralysis occurs and employees exposed may be unaware of danger?

Answer 5

150 ppm

Question 6

Metals and Chemical that can cause peripheral neuropathies?

Answer 6

Metals: lead, arsenic, mercury, thallium
Organophosphate & carbamate pesticides
Acrylamide monomer
Carbon disulfide

Question 7

Organochlorine insecticide , esp chlordane, and lindane are linked to what diseases?

Answer 7

Aplastic anemia and myeloproliferative disorder.

Question 8

Acute Thallium intoxication is treated with?

Answer 8

Potassium chloride and Prussian blue.

Potassium chloride infusion to promote urinary excretion. Prussian blue to bind thallium in the GI tract.

Question 9

Pesticides that causes allergic rhinitis, asthma, and contact dermatitis ?

Answer 9

Pyrethrins, natural pesticides derived from chrysanthemum flowers.

Question 10

Biological monitoring for xylene exposure?

Answer 10

Urine methyl-hippuric acid

Question 11

Polychlorinated biphenyls (PCB) have been linked to?

Answer 11

Neurobehavioral developmental delay.

Infant May be exposed through maternal breast milk secondary to high concentration of PCBs in maternal breast milk.

Question 12

Urine positive for 6-monoacetylmorphine?

Answer 12

Confirmatory for heroin use/abuse

Question 13

9 carboxy-THC positive?

Answer 13

1. A person with no marijuana smoking history who smokes a single marijuana cigarette may test positive for 1-3 days.
2. With repeated smoking, THC accumulates in fatty tissue. Frequent, chronic smokers release THC over a longer time and may continue to produce detectable levels below the cutoff value for a month or long

Question 14

Degreasers’s flush

Answer 14

Can occur in worker’s drinking alcohol following industrial exposure to trichloroethylene vapor.

Question 15

2,3,7,8-TCDD

Answer 15

2,3,7,8-Tetrachloridibenzo-p-Dioxin

Question 16

2,3,7,8-TCDD (Dioxin)

Chronic effect

Answer 16

Chloracne
Soft-tissue sarcoma
Non-Hodgkin lymphoma 
Hodgkin disease
Increased risk of:
   Peripheral neuropathy
   Heart disease
   Liver disease
   Prostate cancer

Question 17

Vinyl chloride monomer

Chronic effect

Answer 17

Hepatic angiosarcoma
Acroosteolysis, Raynaud phenomenon, skin thickening
Hepatosplenomegaly

Question 18

2,3,7,8-TCDD (Dioxin)

Chronic effect

Answer 18

Chloracne
Soft-tissue sarcoma
Non-Hodgkin lymphoma 
Hodgkin disease
Increased risk of:
   Peripheral neuropathy
   Heart disease
   Liver disease
   Prostate cancer

Question 19

Vinyl chloride monomer

Chronic effect

Answer 19

Hepatic angiosarcoma
Acroosteolysis, Raynaud phenomenon, skin thickening
Hepatosplenomegaly

Question 20

PAH

Answer 20

Polycyclic aromatic hydrocarbons

Question 21

PAH

Answer 21

Organic compounds consisting of 3 or more aromatic rings that contain only carbon and hydrogen and share a pair of carbon atom.
Formed by pyrolysis.
Carcinogenic PAHs -those with 5 or 6 rings

Question 22

PAH Occ exposure

Answer 22

Coal tars
Carbon black
Soots -chimney sweeps-scrotal cancer -described by Percivall Pott in 1775

Question 23

PAH carcinogenic

Answer 23

By reactive epoxide formation

Question 24

Styrene
(Vinyl benzene, or phenylenthylene)
Chronic effect

Answer 24

• weakness, HA, fatigue, dizziness

- neuropsychological deficits, color vision loss, sensory nerve conduction slowing

Question 25

Most reliable indicator of Styrene exposure is?

Answer 25

Urine mandelic acid

Question 26

Polychlotinated biphenyls

PCB

Answer 26

Chloracne