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Jason's Locomotor > Opportunistic Infections > Flashcards

Opportunistic Infections Flashcards

1
Q

Local Host factors that affect infection?

A

anatomical defectssurgical woundsburnscatheterisationforeign bodies

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2
Q

systemic host factors?

A

extremes of ageleucopeniamalignancymalnutritiondiabetesliver disease

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3
Q

what infections cause immune suppression?

A

HIVMeasles

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4
Q

2 Sources of opportunistic infections?

A
  1. Endogenous2. exogenous
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5
Q

which strains are often multiresistant?

A

nosocomial

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6
Q

Prevention of opportunistic infections?

A

Hand Hygiene

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7
Q

Pseudomonas is Gram?

A

-ve

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8
Q

Pseudomoas motile or non motile?

A

motile

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9
Q

Pseudomonas fermenting or sporing?

A

None for both

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10
Q

Pseudomonas aerobes? anaerobes?

A

Facultative anaerobes of aerobes

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11
Q

What colour is Pseudomonas pus?

A

pyocyanin

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12
Q

What normal environments do you find Pseudomonas?

A

moist environments: vases, sinks, bathes

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13
Q

what is a saprophyte?

A

grows freely in environment

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14
Q

Where is burkholderia pseudomallei: melioidosis?

A

Northern Territory

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15
Q

Pseudomonas sp. and antibiotics?

A

intrinsically resistant

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16
Q

Pseudomonas major problem in in people with?

A

cystic fibrosis

17
Q

what is a fomite?

A

inanimate objects

18
Q

Pseudomonas acquire resitance how?

A

other bacteria via plasmids

19
Q

pathogenesis of Pseudomonas aeruginosa include 2 big strategies:

A
  1. biofilms

2. quorum sensing

20
Q

2 superficial Pseudomonas aeruginosa infections?

A
  1. skin

2. eye

21
Q

2 deep/systemic infections of Pseudomonas aeruginosa?

A
  1. pulmonary: CF

2. UTI, septicaemia

22
Q

how does Pseudomonas aeruginosa adhere?

A

via flagella, pili, LPS

23
Q

LPS of Pseudomonas aeruginosa binds normally to CFTR, what about in CF?

A

in CF, it’s not locked in so Pseudomonas aeruginosa can form biofilm

24
Q

in biofilm mode: describe Pseudomonas aeruginosa?

A 
increased resistance to antibiotics
non-motile
more capsular/mucoid
less invasive
slower growth
25
Q

What happens when the biofilm reaches quorum?

A

genes change and turn back into bacterial mode

26
Q

how does quorum sensing work in Pseudomonas aeruginosa?

A

light emission at high cell density

27
Q

Why is Pseudomonas aeruginosa in biofilm bad for CF patients?

A

resist mechanical removal

28
Q

Can’t remove Pseudomonas aeruginosa from environment so do what?

A

Prevention

Hand Hygiene

29
Q

Pseudomonas aeruginosa low or high nutritional requirements?

A

Low

30
Q

Pseudomonas aeruginosa prefers when what is reduced?

A

innate immunity

Jason's Locomotor (36 decks)

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