Endocrine disease

Question 1

List the factors that can cause endocrine disease and how they act

Answer 1

Hormone deficiency, hormone excess, hormone resistance (ineffective receptors)

Question 2

List the approaches for treating hormone deficiency

Answer 2

Purify hormone, figure out how to administer and in what quantity, monitor clinical changes and post therapeutic hormone levels

Question 3

Discuss the role of hormone excess in producing endocrine disease

Answer 3

hormone is overproduced by its gland or by tissue that is not an endocrine organ (tumor); endocrine gland tumors produce hormone in an unregulated manner

Question 4

Discuss the effects of compounds such as anabolic steroids in terms of altering endocrine function

Answer 4

willful ingestion of exogenous hormones can be a cause of excess hormone

Question 5

Define: Radioimmunoassay (RIA)

Answer 5

a radioisotope tracing technique that allows the measurement of tiny quantities of insulin and other biological substances in blood

Question 6

Define: Hormone deficiency

Answer 6

endocrine problem often due to a destructive process in the gland in which the hormone is produced (ex.- infection, infarction, tumor, autoimmune attack, genetic defect); also caused by inactivating mutation of receptors

Question 7

Define: Testicular feminization

Answer 7

endocrine disease where cells are unable to respond to androgen and therefore the fetus doesn’t develop male sexual traits

Question 8

Define: Hormone excess

Answer 8

too much hormone is produced either by over-secretion by its designated gland or by tissue that is not an endocrine organ (endocrine gland tumor); ex.- hyperthyroidism, Cushing’s syndrome

Question 9

Define: Hormone replacement

Answer 9

use of a purified or altered hormone to treat hormone deficiency; administered either orally or injected; ex.- Insulin use in diabetes mellitus patients