Sleep disorders

Question 1

Adenosine homeostatsis

Answer 1

Adenosine increases while awake– breakdown of ATP

• high- tire
• low- awake

Question 2

Cytokines interleukin- 1B

Answer 2

increase in the evening and promote sleep

Question 3

Prostaglandin D2

Answer 3

Promotes NREM

Question 4

Circadian Clock

Answer 4

lights out- hypothal releases melatonin

Question 5

Clock genes

Answer 5

Protein synthesis drives the clock

- what you do during the day will regulate what/ how many genes are made for the clock

Question 6

Somnogems

Answer 6

Homeostatic driving forces

Question 7

Zeitgebers

Answer 7

Env. driving forces

Question 8

Isomnia

Answer 8

Difficulty initiating or maintaining sleep

Question 9

Sleep deprevation

Answer 9

leads to decreased brain activity in frontal cortex

Question 10

Hypersomnia

Answer 10

Excessive daytime sleepiness or inability to maintain wakefulness

Question 11

Narcolepsy

Answer 11

Daily sleep abrupt attacks- high emotional states

low or absent orexin or receptors

Question 12

breathing related sleep disorders

Answer 12

Central- brainstem issue

obstructive- aging, weight gain, atrophy

Question 13

Circadian Rhythm sleep disorders

Answer 13

Advanced types- go to sleep too early- old ppl

delayed types- go to sleep too late

Question 14

Nocturnal Myoclonus or periodic limb movement (PLM)

Answer 14

still asleep– not getting stage 4

treated with dopa

Question 15

Restless legs (RLS)

Answer 15

wakeup and have to move around

treated with dopa

Question 16

Nightmare disorder

Answer 16

REM disorder

Pt wakes after

Question 17

Sleep terror disorder

Answer 17

Pt gets up but not consolable
no memory of what happened
Happens during stages 3 and 4

Question 18

Sleep related bruxism

Answer 18

teeth grinding

stage 2

Question 19

Sleeptalking

Answer 19

Somniloquy- happens while asleep and often doesn’t remember

Question 20

Sleep walking

Answer 20

Somnambulism- happens while asleep and often doesn’t remember

Question 21

REM sleep behavior disorder

Answer 21

loss of atonia during REM
acts out dreams- often violently
D2 treatment

Question 22

Sleep related headbanging

Answer 22

Pts rock head back and forth/left and right