6A-ACID/BASE in BLOOD Flashcards Preview

CardioPulmonary > 6A-ACID/BASE in BLOOD > Flashcards

Flashcards in 6A-ACID/BASE in BLOOD Deck (27)
Loading flashcards...
1
Q

Which acid/base system did he teach us?

A

Bronstead-Lowry…Acid=proton donor, Base=Proton acceptor

2
Q

What is the henderson-hasselbeck eq relating CO2 and HCO3-?

A

pH=pKa+log[HCO3-]/[CO2]

3
Q

What is the ratio for Bicarb to CO2 for a neutral 7.4 blood pH?

A

20-bicarb:1-CO2

4
Q

HUGE! What is the normal ECF pH?

A

7.35-7.45

5
Q

What is the approx H+ production by our cells each day?

A

50-100 mEq/L of H+!

6
Q

What are the three acid defense mechanisms in the blood?

A
  1. Bicarb Buffer 2.Phosphate(HPO4 + H+ H2PO4) 3.Protein (amine group accepts OR carboxy grp donates!)
7
Q

With a body pH of 7.16, what is the buffer system going to act as: Acid or Base?

A

With a low pH/acidic condition then buffer system acts as a BASE and soaks up the extra H+

8
Q

With a body pH of 7.64 what is the buffer system going to act as: Acid or Base?

A

With high pH/basic condition the buffer system acts as an ACID and donates more H+

9
Q

Increase in CO2=WHAT in pH?

A

Increase in CO2=DECREASE in pH (acidic)

10
Q

Hypoventalation=WHAT CO2

A

MORE CO2=ACIDIC body conditions

11
Q

Hyperventalation=WHAT CO2

A

LESS CO2=BASIC body conditions

12
Q

The respiratory centers in the brainstem ultimately help regulate the H+ concentration by controlling the ____ and ____ of breathing.

A

rate….depth

13
Q

What are the three ways the kidneys regulate pH?

A
  1. Secreting H+ 2.Reabsorbing HCO3 3.Synthesizing HCO3
14
Q

What does the secretion of H+ by the kidney do to the urine? WHAT part of the kidney is most active in H+ secretion?

A

Urine becomes more acidic…Mainly occurs in the DISTAL CONVOLUTED TUBULE

15
Q

Where does reabsorption of HCO3 AND new synthesis of HCO3 mainly occur in the kidney?

A

Proximal Conv Tubule

16
Q

What are the levels of pH and CO2 in Respiratory Acidosis?

A

LOW pH and HIGH CO2

17
Q

What are the levels of pH and CO2 in Respiratory Alkalosis?

A

HIGH pH and LOW CO2

18
Q

What are the levels of pH and HCO3 in Metabolic Acidosis?

A

LOW pH and LOW HCO3

19
Q

What are the levels of pH and HCO3 in Metabolic Alkalosis?

A

HIGH pH and HIGH HCO3

20
Q

What are these associated with? Emphysema
Pulmonary edema
Chronic bronchitis
Opioid overdose
Neuromuscular disease (e.g., myasthenia gravis, Guillian-Barre syndrome)
Injury to brainstem

A

Respiratory Acidosis

21
Q

What is compensation for Respiratory Acidosis?

A

Buffers act like bases

Kidneys increase their secretion of H+, reabsorption of HCO3- & synthesis of HCO3-

22
Q

All of these cause WHAT?: Breathing at higher altitudes, Anxiety / fear, Salicylic acid (aspirin) overdose (late), Fever

A

Respiratory ALKALOSIS

23
Q

What is compensation for Respiratory Alkalosis?

A

Buffers act like acids
Kidneys decrease their secretion of H+, reabsorption
of HCO3- & synthesis of HCO3-

24
Q

All these cause what? Ketoacidosis, lactic acidosis, anti-freeze poisoning, aspirin OD (early), severe diarrhea.

A

Metabolic Acidosis

25
Q

What is compensation for Metabolic Acidosis?

A

Buffers act like bases, lungs HYPERVENTALATE, KIDNEYS do their THREE actions

26
Q

ALL these cause what? Severe EMESIS, Gastric suctioning, and renal H+ loss?

A

Metabolic Alkalosis

27
Q

What is compensation for metabolic alkalosis?

A

Buffers act like acids, lungs undergo HYPOventalation, kidneys decrease their three things