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Anatomy And Physiology 2 > Urinary System > Flashcards

Urinary System Flashcards

0
Q

Describe the structure of the kidney

A

Located retroperitoneally in perirenal capsul

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1
Q

What are the functions of the urinary system

A

Dispose of metabolic waste and excess substances through formation of urine + filters the blood: gets rid of nitrogenous waste ammonia etc. salts glucose vitamins.
Regulate fluid electrolyte balance. Regulate acid-base balance in blood. Produce hormone erythropoietin

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2
Q

What are the three regions of the kidney

A

Cortex, medulla and pelvis

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3
Q

What is the cortex of the kidney

A

Outer region. Lightly colored and granular

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4
Q

Describe the medulla

A

Darker, reddish brown. Contains cone shaped renal pyramids that are striated. Composed of parallel bundles of urine collecting tubules. The renal pyramid and surrounding cortical tissue constitutes a lobe

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5
Q

Describe the pelvis of the kidney

A

Flat, funnel shaped tube continuous with ureter and exits out the hilium

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6
Q

What are the major calyces

A

Large branches of the renal pelvis that are subdivided into several minor calyces. Collect urine draining from papilla of each renal pyramid. Empty urine into the renal pelvis

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7
Q

How does the urine flow through the pelvis and ureters to the bladder

A

By peristalsis

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8
Q

What are ureters

A

Tubes connecting the renal pelvis to the bladder. Ureters enter bladder at an oblique angle and when bladder is full shape changes and pinches off ureters to prevent backflow of urine

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9
Q

What are the three tissue layers that the wall of the ureter is composed of

A

It are mucosal layer is transitional epithelium. Middle layer is smooth muscle. Outer layer is fibrous

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10
Q

Describe the urinary bladder

A

Stores urine until a limitation. Stretching of wall makes it thinner and more susceptible to rupture. Stretch receptors trigger contractions. Involuntary sphincter control is urine flow into urethra.

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11
Q

Describe the urethra

A

Tube connecting bladder to outside of body. Typically longer in males but not true and cats.

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12
Q

What does the urethra carry in females

A

Urine

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13
Q

What does the urethra carry in males

A

Urine and semen

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14
Q

Describe kidney filtration

A

Kidneys receive one fourth of aortas blood at any given time. All of body’s blood is filtered every five minutes. 25% of blood plasma enters the nephron as filtrate. All but one percent of filtrate is reabsorbed back into the blood by capillories surrounding the nephron that are called peritubular capillaries. Remaining filtrate enters calyces as urine.

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15
Q

Describe blood flow to and from kidneys

A

Aorta ➡️ renal artery➡️afferent arteriole ➡️glomerulus ➡️peritubular capillaries ➡️renal vein ➡️inferior vena cava

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16
Q

How is the kidney capillary bed and the regular capillary bed different

A

This capillary bed is different because it is forced movement not by concentration gradient.

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17
Q

What is the renal corpuscle

A

The glomerulus and the Bowmans capsule

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18
Q

What is a nephron

A

Structural and functional renal unit. Forms urine

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19
Q

What does the nephron consist of

A

Glomerulus
Bowmans capsule
Renal tubule

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20
Q

Describe the glomerulus

A

Capillary bed. Blood enters under high-pressure. Endothelium is fenestrated. Filtration of blood is selective only by size. Filtrate enters the renal tubule after the glomerulus

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21
Q

What can pass through the glomerulus

A

Plasma + dissolved solutes

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22
Q

What shouldn’t pass through the glomerulus

A

Proteins, cells. Too large to be re absorbed and will Be thus present in urine

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23
Q

Describe the Bowmans capsule

A

Surrounds glomerulus and is continuous with the renal tubule. Odor parietal layer is simple squamous epithelium. Inner visceral layer consists of podocytes that cling to basement membrane. Filtrate passes through fenestrations between the feet in the capsule

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24
Q

Where are the pct and dct located

A

The cortex

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25
Q

Where are the loop of henle and the collecting ducts

A

Medulla

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26
Q

Describe the proximal convoluted tubule

A

Simple cuboidal epithelium with microvilli brush border. Reabsorbs water and solids from filtrate and returns to blood via peritubular capillaries. Secrete substances into filtrate.

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27
Q

Describe the loop of Henle

A

Loop of the renal tubule that dips into the medulla.

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28
Q

What are the two portions of the loop of Henle

A

The descending limb and the ascending limb

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29
Q

Describe the descending limb of the loop of Henle

A

Proximal part has cells similar to proximal convoluted tubule then becomes narrow and has simple squamous cells freely permeable to water

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30
Q

Describe the ascending limb of the loop of henle

A

Tube widens again epithelium is cuboidal and columnar and inpermeable to water

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31
Q

Describe the distal convoluted tubule

A

Cuboidal cells without microvilli. Not as twisted as proximal convoluted tubule. Functions more in secretion than reabsorption. Empty into collecting ducts.

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32
Q

Describe the collecting ducts

A

Receive filtrate from numerous distal convoluted tubule’s. Deliver filtrate to renal pelvis. Composed of two cuboidal cell types. Principal cells maintain water and potassium balance and intercalcated cells maintain acid-base balance and have microvilli

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33
Q

Describe the glomerulus capillary bed

A

Fed by afferent arteriole, drained by efferent arteriole. Produces filtrate

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34
Q

Describe the peritubular capillaries

A

Site of reabsorption and secretes. Site of gas exchange. Merge to form renal vein

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35
Q

What are the three major processes in urine formation and adjustment of blood composition

A

Glomerulus filtration
Tubular reabsorption
Tubular secretion

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36
Q

Describe filtration

A

Occurs at glomerulus, size selective only

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37
Q

Describe reabsorption

A

Tubule➡️peritubular capillaries. Good stuff lost at glomerulus is returned to blood unless in excess. All of glucose and amino acids should be reabsorbed

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38
Q

Describe secretion

A

️peritubular capillaries ➡️ tubules. Bad stuff not filtered in glomerulus transported to tubule for excretion

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39
Q

Where should reabsorbed and secreted substances also pass through

A

Institial space between vessels and nephron. Transport may be passive (diffusion) or active (ATP). Osmotic gradient in medulla affects transport

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40
Q

How does urine volume regulation work

A

Amount of water reabsorbed by dct and collecting ducts is variable.

41
Q

What is urine volume influence by

A

Influenced by adh and aldersterone. Also influenced by pathologies such as diabetes mellitis

42
Q

What does adh do to the urine

A

Affects water transport proteins in dct and collecting tubules.

43
Q

What is diabetes insipidus

A

Pu/pd: caused by inadequate adh release from posteur petuitary (central DI) or non responsive tubule cells (nephrogenic DI)

44
Q

What happen when no ADH is present

A

Collecting duct is not permeable to water and a large volume of urine is produced

45
Q

What happens when no adh is present

A

Collecting duct is permeable to water and a small volume of urine is produced

46
Q

What does aldersterone do

A

Acts on DcT and collecting duct cells. Increases reabsorption of NA+ which causes water to follow if adh is present

47
Q

What is the renal threshold of glucose

A

Limited amount of glucose can be reabsorbed by pct into blood. Excess remains in filtrate/urine

48
Q

What is BUN

A

Urea in blood

49
Q

What does high glucose in filtrate cause

A

Increased water secretion➡️ increased urine volume ➡️ dehydration and pu/pd

50
Q

What is the dogs renal threshold

A

180mg/dl

51
Q

What is the cats renal threshold

A

240mg/dl

52
Q

What is urination called

A

Mucturation and uresis

53
Q

What is normal urine output

A

1-2 ml/kg/hr.

54
Q

What can urine output show

A

Can provide info about renal function. Affected by other fluid losses (vomiting) and fluid input (iv).

55
Q

What is the best way to measure urine output

A

With an indwelling urinary catheter

56
Q

What is the glomerulus filtration rate

A

Volume of blood filtered by glomerulus and entering Bowmans capsule per unit of time. Affected by blood pressure and blood volume. Want a relatively steady rate of GFR

57
Q

What can high GFR show

A

Not enough time for all substances to be filtered, secreted and reabsorbed

58
Q

What is low GFR

A

Too much time for reabsorption, substances that should have been excreted and reabsorbed

59
Q

What can GFR be used to measure

A

Renal function

60
Q

How do you measure kidney function?

A

Serum creatinine concentration test

Plasma clearance of substance

61
Q

What is the serum creatinine concentration test

A

Creatinine is a waste product of muscle cells which travels in blood and is excreted in urine. Amount produced and excreted depends on muscle mass but is relatively constant in an individual. Measure amount of creatinine in urine. If elevated, may indicate renal dysfunction.

62
Q

What is the advantage to the serum creatinine concentration test

A

Cheap and easy

63
Q

What is the disadvantage to the serum creatinine concentration test

A

Not really sensitive. GFR needs to be 75% less than normal for a change to be detected.

64
Q

What is the plasma clearance of substance

A

Inject a substance Into the blood, measure the amount of time it takes for the blood to be cleared of the substance: need to take blood samples at regular intervals. Want to use a substance that is not normally present in the blood and one that will not be reabsorbed into blood or secreted back into tubules or metabolized. Test blood samples for presence of substance

65
Q

What is renal dysfunction

A

Kidneys are unable to remove waste from blood, nitrogen waste builds up in blood and is measurable.

66
Q

What is azotemia

A

Abnormally high levels of nitrogen waste in blood but no symptoms in individual

67
Q

What is item is

A

Abnormally high level of nitrogen waste in blood that now produces symptoms

68
Q

How do you test for renal dysfunction

A

Measure bun

69
Q

What is prerenal uremia

A

Kidney fx normally but decreases blood flow to kidneys so they cannot remove waste properly. Due to dehydration etc

70
Q

What is renal uremia

A

Damage to nephrons due to toxins; acute or chronic

71
Q

What is post renal uremia

A

Due to blockage after kidney can lead to renal uremia

72
Q

What is dialysis

A

Diffusion of substances through a semi permeable membrane

73
Q

What is hemodialysis

A

Blood is removed from animal and filtered into a machine : 4-6hrs

74
Q

What is continuous renal replacement therapy

A

Similar to hemodialysis but slower; takes 12hrs

75
Q

What is peritoneal dialysis

A

Fluid introduced into peritoneal cavity then flushed out

76
Q

What is bacterial cystitis

A

Bladder infection, most common in dogs, usually due to bacteria travelling up from urethra

77
Q

What are the signs of bacterial cystitis in Dogs

A

Pollakiuria, hematuria, Dysuria, cloudy urine, frequent licking of urethra

78
Q

How do you test for bacterial cystitis in dogs and what is the treatment

A

Urinalysis and the treatment is antibiotics

79
Q

What can cystitis also be caused by

A

Stones, tumors or be idiopathic

80
Q

What is feline lower urinary tract disease

A

Collection of disorders affecting bladder and urethra. Can be caused by presence of uroliths, infection, tumor or can be idiopathic.

81
Q

What are the signs of feline lower urinary tract disease

A

Stranguria, Dysuria, hematuria, frequent licking, innapropriate urination

82
Q

What is the treatment of flutd

A

Depends on the cause. UA can help in diagnosis

83
Q

What is urethral obstruction

A

Most common in male cats due to caudal location of penis. Urethra curves and narrows near penis. Can be fatal in 36-48hrs.

84
Q

What are the signs of urinary obstruction

A

Anuria, Dysuria, stranguria, hematuria, rigid bladder, innapropriate urination

85
Q

What is the treatment for urethral obstruction

A

Catheterization, cystotomy to remove calculi, or perineal urethrostomy to widen the urethra

86
Q

What urolithiasis

A

Formation of uroliths in urinary tract. Symptoms are dependant on location and size. Some animals are asymptomatic. tx involves surgery and dietary changes

87
Q

Why do urolithiasis form

A

Normally substances in Urine remains dissolved but will precipitate and forms crystals and under certain conditions. Composed mainly of minerals. Removed surgically or using lithotripsy

88
Q

What is urethral duplication

A

Extra urethras

89
Q

What is uranalysis

A

Tests to evaluate physical and chemical properties of urine.

90
Q

What are the urine collecting methods

A

Free catch, catheterization, and cystocentesis

91
Q

How do you do urine specimen processing

A

Collect in clear container without additives. Ideally analyze sample immediately after collection. Refrigerate up to four hours. Reduces bacteria growth but may cause crystallization. Allow sample to warm to rt before testing.

92
Q

What are the physical properties of urine processing

A

Color, transparency and specific gravity

93
Q

What is specific gravity

A

Amount of dissolved solutes in urine

94
Q

What are the chemical properties of urine specimen processing

A

Use dip stick for color change.

95
Q

What is microscopic urine analysis

A

Centrifuge sample, examine sediment looking for presence of cells and casts

96
Q

What are casts

A

Cylindrical aggregation of substances

97
Q

What is crystalluria

A

Crystals in urine

98
Q

What are struvites

A

Can be caused by more alkaline ph. Most common crystals in cats and dogs.

99
Q

What is calcium oxalate stones

A

Can be caused by more acidic ph. Common in cats

Anatomy And Physiology 2 (12 decks)

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