Week 3 - Immune System Overview Flashcards
0
Q
What TLRs detect Bacterial Infections?
A
TLR4- LPS (gram negative)
TLR5 - Flagellins
1
Q
What are the 3 basic layers of the immune system?
A
- Physical Layer
- Innate Immune System
- Adaptive Immune System
2
Q
What TLRs detect Viral Infections?
A
TLR9 - CpGRNA
TLR13 - dsRNA
(in an endosome)
3
Q
What is the stratum corneum?
A
It is made up of dead cells/terminally differentiated/Non-living keratinocytes.
- Make up protective layer of skin
- Cells dry, regenerate, dec. pH, inc. salt
4
Q
What does IL-2 do?
A
Proliferative - drives T cells to grow & divide
5
Q
What does IL-12 do?
A
T cell differentiation to Th1
6
Q
What does IL-4 do?
A
T cell differentiation to Th2
7
Q
What are INF-gamma and TNF-beta?
A
Proinflammatory - Th1
8
Q
What does IL-4 and IL-5 do?
A
It helps activate eosinophils & mast cells: force class switch maturation (to IgE) [Th2] -When class switch is done inappropriately, it causes hay fever
