3

Question 1

What kind of cell death is due to irreversible cell injury?

Answer 1

necrosis

Question 2

T-F–apoptosis occurs during programmed cell death in proliferating tissues, but is not a response to specific types of injury?

Answer 2

False—virus, t-cell killing, radiation are specific types of injury that where apoptosis occurs

Question 3

What is type II programmed cell death? What is the main component of this?

Answer 3

Autophagy

-lysosomal digestion of the cells own components

Question 4

What type of cell death-non-physiologic?

Answer 4

necrosis

Question 5

What type of cell death-non-physiologic and physiologic?

Answer 5

apoptosis

Question 6

What type of cell death-no gene transcription of protein synthesis?

Answer 6

necrosis

Question 7

What type of cell death-highly regulated?

Answer 7

apoptosis

Question 8

What type of cell death-no energy required?

Answer 8

necrosis

Question 9

What type of cell death-energy dependent?

Answer 9

apoptosis

Question 10

What type of cell death-random chromatin cleavage?

Answer 10

necorsis

Question 11

What type of cell death-endonuclease cleavage of chromatin (DNA ladder)?

Answer 11

apoptosis

Question 12

What type of cell death-lysosomes stay intact?

Answer 12

apoptosis

Question 13

What type of cell death-cell membrane leakage?

Answer 13

necrosis

Question 14

What type of cell death-death of individual cells?

Answer 14

apoptosis

Question 15

What type of cell death-karyolysis and karyorrhexis?

Answer 15

necrosis

Question 16

What is karyolysis?

Answer 16

loss of basophilic nuclear staining due to complete dissolution of the chromatin matter due to DNAase

Question 17

What is karyorrhexis?

Answer 17

nuclear fragmentation

Question 18

What type of cell death-cell organelles preserved?

Answer 18

apoptosis and irregular chromatin distribution throughout cytoplasm.

Question 19

What type of cell death-cell swelling?

Answer 19

necrosis

Question 20

What type of cell death-cell shrinkage?

Answer 20

apoptosis

Question 21

What type of cell death-eosinophilia?

Answer 21

necrosis

Question 22

What type of cell death-phagocytosis by adjacent cells?

Answer 22

apoptosis

Question 23

What type of cell death-inflammatory response?

Answer 23

necrosis

Question 24

what is irreversible condensation of chromatin in the nucleus of a cell?

Answer 24

pyknosis

Question 25

What the of necrosis-injury and acidification denatures proteins, but there is preservation of cell outlines and tissue structure?

Answer 25

coagulative necrosis

Question 26

What type of necrosis-heterolysis, catalytic enzymes, no cell outlines?

Answer 26

liquefactive

Question 27

What type of necrosis- cheesy white appearance?

Answer 27

caseous necrosis

Question 28

What does fatty acids complex with in enzymatic fat necrosis?

Answer 28

calcium-saponification

Question 29

How much of our neurons die during development due to apoptosis?

Answer 29

50%

Question 30

T-F---necrosis is the method for destroying self reactive lymphoid cells>

Answer 30

false…apoptosis

Question 31

What gene/proteins does apoptosis require?

Answer 31

Bax and/or Bak

Question 32

What type of cell death-emphasis is placed on limiting injury?

Answer 32

necrosis

Question 33

What type of cell death-genetic biochemical pathway that can be pharmacologically manipulated?

Answer 33

apoptosis

Question 34

What type of disease do we want to promote apoptosis?

Answer 34

cancer

Question 35

what type of disease do we want to inhibit apoptosis?

Answer 35

neurodegeneration/ischemia

Question 36

Is p53 a pro-oncogene?

Answer 36

no it is a tumor suppressor

Question 37

T-F---viruses can block apoptosis?

Answer 37

True

Question 38

What is the main convergence in pathways during apoptosis?

Answer 38

caspase 3-executioner caspases | [he also has 7 listed but doesn't seem to think its that big of a deal like 3]

Question 39

What type of cell death-condensed nuclear staining is spread randomly throughout the tissue?

Answer 39

apoptosis [punctate basophilic nuclei will be spread sporadically in the tissue

Question 40

extrinsic vs intrinsic apoptosis- mitochondrial permeabilization?

Answer 40

intrinsic

Question 41

What protein family controls intrinsic permeabilization?

Answer 41

Bcl-2

Question 42

Extrinsic vs. Intrinsic apoptosis-Fas, TNF, Trail?

Answer 42

Extrinsic---ligands bind to surface receptors

Question 43

How does Bax/Bak work?

Answer 43

forma pore that releases Cytochrome C from the inner-membrane---Bcl-2 typically blocks formation of this pore

Question 44

What pathway is defective in patients with autoimmune lymph proliferative syndrome?

Answer 44

defects in extrinsic apoptosis [FAS specifically] | --->increased lymphocyte survival

Question 45

What protein is the main study for enhanced apoptosis?

Answer 45

Bcl-2 antagonists

Question 46

T-F---defects in autophagy may lead to cancer?

Answer 46

True

Question 47

T-F---their is an interest in activating autophagy in neurodegenerative disease?

Answer 47

true--increase removal of misfiled proteins or damaged mitochondria

Question 48

Where does the pink1 protein accumulate normally?

Answer 48

inter membrane space of mitoch.

Question 49

Where does pink1 accumulate following loss of mitoch transmembrane potential?

Answer 49

outer mitoch. membrane

Question 50

What does pink1 in the wrong place cause?

Answer 50

recruitment of parkin, mitophagy

Question 51

What disease is associated with pink1/parkin defects?

Answer 51

parkinsons