Hepatitis Tx II Flashcards
MOA ribavirin
inhibits initiation/elongation RNA causing inhibition viral protein synthesis
adverse effects ribavirin
dose dependent hemolytic anemia, depression, fatigue, nausea, rash, insomnia
teratogenic, embryotoxic, oncogenic and maybe gonadotoxic
Therapeutic use ribavirin
chronic HCV in combo with peginterferon alfa and sofosbuvir
Influenza A B and RSV, paramyxoviruses and HIV-1
contraindications to ribavirin
anemia, end stage renal failure, ischemic vascular disease, pregnancy (and partners)
MOA sofosbuvir
direct acting antiviral, inhibits HCV NS5B RNA dependent RNA polymerase and is chain terminator
adverse effects sofosbuvir
fatigue, HA, insomnia, pruritis, nausea, diarrhea, flu-like Sx, anemia, neutropenia, weakness and myalgia
therapeutic use sofosbuvir
HCV
limit of sofosbuvir
cost! super duper stupid expensive. fuck pharmaceuticals
MOA simeprevir
direct acting antiviral, inhibits HCV NS3/4A protease which is needed for viral replication
how is simeprevir metabolized
CYP3A4
adverse effects simeprevir
skin rash, pruritis, nausea, increased serum bilirubin, myalgia
therapeutic use simprevir
HCV
drug interactions simeprevir
CYP inducers like rifampin will dec the simeprevir levels
may increase statins
limit of simeprevir
again. fuck pharmaceutical companies
what drugs are no longer recommended for HCV
boceprevir and telaprevir, the protease inhibitors
