31 CNS Drugs 1,2

Question 1

Ketamine & Phencyclidine (PCP) are part of ______ signaling systems and act on their targets by what mechanism?

Answer 1

Glutamate, NMDA receptor ANTAGONIST (Non-comp)

Question 2

Diazepam, Midazolam, Flunitrazepam (date rape drug) are part of ______ signaling systems and act on their targets by what mechanism?

Answer 2

All Benzo’s- end in p(l)AM. GABA, GABA(A) receptor (up)Modulators (Wide-Range of subtypes).

GABA must be present

Used for Anxiety, Epilepsy, Insomnia

Tolerance, dependence problems

Question 3

Zolpidem, Eszopiclone are part of ______ signaling systems and act on their targets by what mechanism?

Answer 3

GABA, GABA(A) receptor modulators (Narrow-Range of SUbtypes).

Question 4

Baclofen is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 4

GABA, GABA(B) receptor Agonist.

Question 5

Strychnine is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 5

Glycine, Glycine Receptor ANTAGONIST.

Give Glycine for Strychnine poisoning.

Question 6

L-DOPA is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 6

Dopamine, Substrate for Dopamine synthesis- can cross BBB

D1 receptors INCREASE cAMP levels

D2 receptors DECREAE cAMP levels

Question 7

Amphetamines are part of ______ signaling systems and act on their targets by what mechanism?

Answer 7

Dopamine, Increases vesicular dopamine release.

Question 8

Haloperidol is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 8

Dopamine, Dopamine D(2) receptor ANTAGONIST (stops the lowering of cAMP)

Used as antippsychotic

Question 9

Cocaine is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 9

Dopamine, Dopamine reuptake inhibitor.

Question 10

Fluoxetine is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 10

Serotonin, Selective Serotonin reuptake inhibitor (SSRI).

Used for Anxiety (Prozac)

Question 11

Clonidine is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 11

Norepinephrine, Alpha(2) Adrenoceptor Agonist.

Used in opiate withdrawl causing hyperarousal

Question 12

Nicotine is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 12

Acetylcholine, Nicotinic Acetylcholine Receptor Agonist.

Question 13

Carbamazepine is part of ______ signaling systems and acts on its targets by what mechanism?

Answer 13

Voltage-Gated Ion Channels, Use-Dependent Voltage Gated SODIUM Channel BLOCKER.

Used for Epilepsy, Trigeminal neuralgia (anticonvulsant by inhibiting repetitive neuronal firing)

—— Arrhythmia, HTN, local anethesia

Question 14

COMT with a Val AA varient

Answer 14

Val varient means COMT works faster to break down Dopamine (unwanted)

Give COMT inhibitors