Antipsychotics Flashcards
positive characteristics of schizophrenia:
religious delusions
hallucinations
paranoia
negative characteristics of schizophrenia:
apathy lack of motivation inability to think and communicate lack of energy withdrawal from society
Schizophrenia is due to an overproduction of _____ OR oversensitivity of ____ _____
in the meso-_____ and meso-_____ areas of the brain
dopamine
dopamine receptors
mesolimbic
mesocortical
Newer atypical antipsychotics are ____ (more/less) effective than older typical antipsychotics
Called “atypical” because of less side effects, first choice drugs over older typical
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Side effect of older typical antipsychotics due to blocking of other receptors:
extrapyramidal effects similar to Parkinson’s disease
side effects of older typical antipsychotics:
severe stiffness called ___ _____
pacing and restlessness called _____
movements of the face called ____ _____
acute dystonia
akathisia
tardive dyskinesia
drug used short-term to sedate severe behavior of schizophrenia: _____
very sedative
AE: extrapyramidal reactions, reduced by ____
Haloperidol
Cogentin
Older typical drug no longer used: _____
strong anticholinergic effects: dry mouth
Thorazine
Atypical antipsychotics block both _____ and ______ receptors
some AE: sedation
weight gain
hyperglycemia
serotonin
dopamine D2
first atypical on the market: ____
rarely prescribed due to risk of ________
weekly blood testing required
Clozapine
agranulocytosis
common atypical drug: ______
active metabolite of it: ______
Risperdal
Paliperidone
atypical with major weight gain effect: ____
olanzapine
other atypical drugs
Seroquel, Abilify, Geodon
Antiemetics reduce: ______ by blocking dopamine receptors in the _____ at the medulla oblongata
nausea/vomiting
CTZ (chemoreceptor trigger zone)
antiemetic effective for most forms of nausea, but not chemotherapy: ________
AE: parkinsons effects, blurred vision, dry mouth
Prochlorperazine
