TBL 23 Flashcards

1
Q

What is the perineum?

A

It is a subcutaneous compartment immediately inferior to the pelvic diaphragm between the superomedial thighs.

When the lower limbs are abducted, the perineum is diamond-shaped extending from the pubic symphysis to the tip of the coccyx and between the ischial tuberosities.

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2
Q

What does the imaginary line between the tuberosities create?

A

anterior UG triangle (occupied by the genitilia and urethra) and posterior anal triangle (anal canal and anus)

central point = perineal body

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3
Q

What is the importance of the urogenital hiatus?

A

It enables the urethra and in females, the vagina, to exit the pelvic cavity.

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4
Q

What is the perineal membrane?

A

It is the fascial sheet that spans across the urogenital hiatus and stretches between the ischiopubic rami to cover the UG triangle.

It separates the UG triangle into the deep and superficial pouches.

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5
Q

What happens to the urethra in relation to the perineal membrane?

A

The urethra traverses the urogenital hiatus into the deep pouch, which is superior to the perineal membrane. After perforating the perineal membrane, the urethra enters the superficial pouch that is inferior to the perineal membrane.

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6
Q

What covers the perineal triangles?

A

Skin and subcutaneous fascia.

Like fascia of the anterolateral abdominal wall below the umblicus, the perineal fascia consists of a superficial fatty layer representing the continuation of Camper’s fascia and a deep fibrous layer (Colles fascia), that is a continuation of Scarpa’s fascia.

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7
Q

Describe Colles fascia in female perineum.

A

There is continuity of Scarpa’s fascia with Colles fascia here.

It extends to the perineal body, which marks the center of the posterior margin of the perineal membrane. Like the perineal membrane, Colles fascia only covers the UG triangle.

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8
Q

Describe Scarpas, dartos, and Colles fascia in males.

A

In males Scarpa’s fascia is continuous with the dartos fascia on the penis and scrotum.

Dartos (smooth) muscle joins the dartos fascia on the scrotum. Posterior to the scrotum, the dartos fascia is continuous with Colles fascia.

Colles fascia extends to the posterior margin of the perineal membrane.

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9
Q

Where does the perineal membrane stretch?

A

between the ischiopubic rami and it separates the deep and superficial pouches

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10
Q

What does the deep pouch contain?

A

It is the shallow space between the pelvic diaphragm and perineal membrane.

Contains the voluntary external urethral spincter and compressor urethrae, a slip of skeletal muscle from the pubococcygeus in females. Also has the deep transverse perineal muscle, which is a slip of involuntary smooth muscle from the muscluaris externa of the superior part of the anal canal (both sexes).

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11
Q

What is contained in the superficial pouch?

A

perineal membrane that acts as a foundation for the bulb and crura of the penis, body of the clitoris, associated erectile tissues (these are covered by thin sheets of skeletal muscle)

these structures of the superficial pouch are covered by dartos fascia in males and Colles fascia in both sexes

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12
Q

What is the superficial transverse perineal muscle?

A

slip of smooth muscle from the muscularis externa of the anal canal.

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13
Q

What happens to the perineal fascia in both sexes?

A

The fatty layer of the perineal fascia extends posteriorly into the ischioanal fossae, which are filled with white fat and surround the anal canal.

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14
Q

What is in the anal triangle? and what lies at the site of covergence?

A

anal triangle: voluntary external anal sphincter

site of convergence: perineal body, transverse perineal muscles and bulbospongiosus

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15
Q

Why is the anal triangle not separated into superficial and deep pouches?

A

perineal membrane and Colles fascia do not extend into the anal triangle.

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16
Q

What clinical consequences can occur if the perineal body is damaged during childbirth?

A

There will be a prolapse of pelvic viscera, including prolapse of the bladder (through the urethra), and prolapse of the uterus and/or vagina through the vaginal orifice.

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17
Q

Why is a mediolateral episiotomy preferable to a median episiotomy?

A

Episiotomy: surgical incision of the perineum and inferoposterior vaginal wall. it is used to enlarge the vaginal orifice to decrease excessive traumatic tearing of the perineum and uncontrolled jagged tears of the perineal muscles.

Mediolateral episiotomies result in lower incidence of severe laceration and are less likely to be associated with damage to the anal sphincters and canal. It circumvents the perineal body unlike the median episiotomy.

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18
Q

What forms the pudendal canal and what does it do?

A

Obturator fascia, which covers the medial surface of the obturator internus muscle, forms the pudendal canal.

The pudendal canal creates a horizontal passageway in the perineum for the internal pudendal artery and pudendal nerve (S2-S4).

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19
Q

What are the branches of the anterior division of the internal iliac artery?

A

anterior division of the internal iliac artery: pelvic viscera

Inferior gluteal arteries

pudendal artery: supplies the perineum

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20
Q

What is a branch of the posterior division of the internal iliac artery?

A

posterior division of internal iliac artery: posterior abdominal wall

superior gluteal artery

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21
Q

Where do the pudendal artery and nerve emerge from?

A

The greater sciatic foramen into the gluteal region.

They immediately hook around the sacrospinous ligament to traverse the lesser sciatic foramen into the perineum where they descend to the pudendal canal

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22
Q

What do the pudendal nerve and inferior rectal nerve do?

A

Pudendal nerve provides somatic motor and sensory fibers to the perineum.

The inferior rectal nerve (branch of the pudendal nerve) courses through the white fat of the ischioanal fossae to innervate the external anal sphincter and anus

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23
Q

What is the cloacal membrane? What is the cloaca divided into?

A

It respresents the fused surface ectoderm and cloacal endoderm.

The cloaca is divided into the anterior urogential sinus and posterior anorectal canal by the urorectal septum. The tip of the septum forms the perineal body.

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24
Q

What forms the genital tubercle? What happens caudal to the genital tubercle?

A

Mesenchymal cells migrate onto the surface of the cloacal membrane to form a pair of elevated cloacal folds that join cranially to form the genital tubercle.

Caudal to the genital tubercle, the cloacal folds are separated into anterior urethral folds and posterior anal fold.

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25
Q

What happens to the genital tubercle under the influence of testosterone?

A

The genital tubercle elongates rapidly to form the phallus

The phallus pulls the urethral folds forward thereby forming the lateral walls of the urethral groove. Closure of the groove forms the penile urethra.

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26
Q

What is hypospadias and where is it likely to occur?

A

Hypospadias: fusion of the urethral folds is incomplete and abnormal openings of the urethra occur along the inferior aspect of the penis, usually near the glans, along the shaft, or near the base of the penis.

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27
Q

What forms on the sides of the urethral folds?

A

another pair of elevations form the bilateral genital swellings

each genital swelling becomes a scrotal swelling composed of heavily pigmented skin that overlies the dartos fascia and muscle

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28
Q

What creates the scrotum?

A

During dissension of the testis and spermatic cord from the superficial ring of the inguinal canal, each genital swelling moves caudally to create half of the scrotum.

Midline fusion of the swellings forms the scrotal septum.

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29
Q

What happens to the prostatic urethra?

A

It becomes the membranous urethra in the deep perineal pouch.

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30
Q

What surrounds the urethra?

A

external urethral sphincter

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31
Q

What happens to the spongy (penile) urethra?

A

After perforating the perineal membrane, into the superficial pouch, the urethra courses through the root, body and glans of the penis.

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32
Q

How do the sites of the urine extravasation differ after injury to the penile and membranous urethra?

A

Penile urethra: superficial pouch

membranous urethra: deep pouch

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33
Q

What surrounds the penile urethra along its entire course?

A

Bulb of the penile root which is continuous with the corpus spongiosum

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34
Q

What do the crura of the penile root and corpus cavernosa do?

A

They are continuous with one another and course parallel to the urethra in the root and body of the penis

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35
Q

What does the bulbospongiosus muscle do? ischiocavernosus muscle?

A

bulbospongiosus muscle: covers the bulb

ischiocavernosus muscle: covers the bilateral crura

36
Q

What does erectile tissue consist of?

A

dense connective tissue surrounding venous sinuses and muscular helicine (convoluted) arteries

37
Q

Where are helicine arteries generated from?

A

internal pudendal artery.

The arteries empty directly into the venous sinuses of the penile erectile tissues

38
Q

What do pudendal nerves do?

A

they support and transport postsynaptic sympathetic fibers that mediate tonic convolution of the helicine arteries

tonic convolution normally restricts blood flow into the venous sinuses

39
Q

What do the cavernous nerves of the prostatic plexus, branches of the parasympathetic pelvic splanchnic nerves do?

A

It inhibits the sympathetic-mediated tonic convolutions. The resultant uncoiling of the helicine arteries engorges the venous sinuses with blood to induce penile erection.

40
Q

Why can radical prostatectomy cause erectile dysfunction?

A

Plexus on the prostate that contains nerves that inhibits contraction of arteries so more blood from arteries to veins–> induces penile erection

41
Q

What does sympathetic mediated contraction of smooth muscle do?

A

smooth muscle in the vas deferens, seminal vesicles, and ejaculatory ducts delivers semen to the prostatic urethra

prostatic fibromuscular stroma and pudendal nerve-mediated contraction of the thin bulbospongiosus muscle = ejaculation

42
Q

What type of innervation do the posterior and anterior surfaces of the scrotum receive?

A

somatic sensory innervations from the pudendal nerve (posterior) and ilioinguinal nerve (anterior)

43
Q

What happens to the scrotum in response to the cold?

A

In response to cold, sympathetic fibers conveyed by the two somatic nerves involuntarily contract the dartos muscle to decrease the scrotal surface area, which maintains scrotal temperature a few degrees below body temperature to insure spermatogenesis.

The pampiniform venous plexus of the spermatic cord contributes to this thermoregulatory function by cooling the blood in the testicular arteries.

44
Q

How does primary lymph drainage from the penis and scrotum differ from lymph drainage from the testes?

A

penis and scrotum: superficial inguinal or deep inguinal or internal iliac

testes: external iliac

45
Q

Why do injection sites differ for anesthetizing the anterior and posterior surfaces of the scrotum?

A

The anterolateral surface of the scrotum is supplied by the lumbar plexus (L1) and the postero-inferior aspect is supplied by the sacral plexus (S3), a spinal anesthetic agent must be injected more superiorly to anesthetize the anterolateral surface of the scrotum than is necessary to anesthetize its poster-inferior surface.

46
Q

How can testicular cancer of the scrotum be distinguished by lymphogenous metastasis?

A

Cancer of testis: metastasizes initially to the lumbar lymph nodes

Cancer of the scrotum: metastasizes to the superficial inguinal lymph nodes

47
Q

What happens after germ cells invade the indifferent gonads?

A

proliferation of the primitive sex cords creates testis cords, which transforms the gonads into the testes.

The testis cords are separated from the genital ridge epithelium by a layer of dense connective tissue designated the tunica albuginea.

48
Q

What forms the rete testis?

A

portions of the testis cords adjacent to the intermediate mesoderm form short tubules.

at puberty, the solid testis cords acquire a lumen to become seminiferous tubules.

49
Q

What forms the efferent ductules? What happens below the efferent ductules?

A

mesonephric duct generates efferent ductules that unite with the rete testis.

below the efferent ductules, the mesonephric duct –> the convoluted epididymis –> from outbudding of the seminal vesicle, the mesonephric duct makes the vas deferens

50
Q

What accommodates the rete testis? What lines the seminiferous tubules?

A

rete testis: tunica albuginea is thickened along the posterior border of the testis

seminferous tubules: lined by stratified epithelium. It is made up of Sertoli cells (derivatives of genital ridge epithelium) and spermatogenic cells (derived from germ cells)

51
Q

Where do spermatogonia reside and what does their continuous renewal generate?

A

reside on the basement membrane

continuous renewal generates spermatocytes with dark spherical nuclei that become progressively smaller as the cells move toward the tubular lumen. (nonproliferation, columnar shaped Sertoli cells extend from the basement membrane to the tubular lumen)

52
Q

How are Sertoli cells important in spermatogenesis?

A

Their apices bear crypt-like recesses that hold spermatids until release of newly formed spermatozoa into the lumen.

Adjacent cells are linked by baso-lateral tight junctions so the epithelium is divided into basal and adluminal compartments. The blood-testis permeability barrier separates spermatogonia and primary spermatocytes from more apical secondary spermatocytes and spermatids. Contents in seminiferous tubules are isolated from circulated antigens! this protects spermatocytes and spermatids from autoimmune reactions and blood-borne substances.

53
Q

Describe a mature spermatozoa.

A

Maturation of the spermatocyte-derived spermatozoa completes spermatogenesis.

Head = condensed nucled with surrounding acrosome that contains proteolytic enzymes that allow easy penetration of the corona radiata at fertilization

middle: filled with mitochondria that provide energy to cilium
tail: mobile cilium

54
Q

What are Leydig cells?

A

Leydig cells are mesoderm derived. They reside in the loose connective tissue between the seminiferous tubules. Under LH stimulation, Leydig cells locally release testosterone which is needed for spermatogenesis. This testosterone, which enters the blood stream, is essential for normal functioning of the prostate and seminal vesicles.

55
Q

What is the epididymis? How are spermatozoa affected by the epididymal epithelium during their passage in the epididymis?

A

Epididymis: long passageway between efferent ductules and vas deferens

Spermatozoa mature and acquire motility and fertilizing capacity.

56
Q

What are seminomas and what is their relationship to cryptorchidism?

A

Seminomas = invasive germinal cell tumors that are thought to arise from germinal epithelium

cryptorchidism: undescended testis predisposes boys to develop germ cell tumors

57
Q

What is the potential for surgical reversal of a vastectomy? Does a vastectomy affect endocrine function of the testes?

A

Vastectomy: produce permanent sterility by preventing transport of spermatozoa out of the testis. Ducutus deferns can be cut and the two ends tied/ cauterized.

Microsurgery can reverse.

Endocrine function = none

58
Q

What is the pathogenesis of epididymitis and what is the possible consequence of severe bilateral cases?

A

Inflammation of the epididymis. Bilateral epididymitis can lead to male infertility.

59
Q

What does estrogen do to the genital tubercle?

A

Estrogen from the developing ovaries stimulates slight elongation of the genital tubercle to form the clitoris

60
Q

What forms the erectile tissue in the clitoris?

A

Corpus cavernosa

61
Q

What forms the thin labia minora? labia majora?

A

Urethral folds –> thin labia minora that demarcate the open vestibule

labia majora –> thick folds that come from genital swellings. it merges anteriorly to form the mons pubis

62
Q

What happens in the vestibule?

A

Vaginal orifice is posterior to the external urethral orifice

urethra comes from the inferior portion of the UG sinus

63
Q

What are components of the vulva?

A

Clitoris
Labia majora and minora
Vesticule
Mons pubis

64
Q

Where does lymph from the vulva drain into?

A

superficial inguinal lymph nodes

65
Q

What is located in the superficial perineal pouch?

A

The bulbs of the vestibule and vestibular glands are covered by the bulbospongiosus muscles

During sexual arousal, contraction of the bulbospongiosus expedites mucus secretion from the glands into the vestibule.

66
Q

What covers the superficial pouch?

A

Fatty layer of perineal fascia cover the superficial pouch thickens to form the fatty cores of the labia majora and mons pubis

67
Q

What forms the uterine canal?

A

Midline fusion of the paramesonephric ducts forms the uterine canal.

the canal terminates at the wall of the urogenital sinus. solid evaginations from the uterine canal and urogenital sinus form a tissue wedge between them

68
Q

How are the vagina and vaginal formix formed?

A

Vacuolization of the portions of the wedge formed by the urogenital sinus (vagina) and uterine canal (vaginal formix)

69
Q

What malformation creates the urorectal and rectovaginal fistulas?

A

They are formed by abnormalities in formation of the cloaca and/or urorectal septum.

(Example: if the cloaca is too small, or if the urorectal septum does not extend far enough caudally, then opening of the hindgut shifts anteriorly leading to an opening of the hindgut into the urethra or vagina)

70
Q

What is the relationship of the exocervix to the vaginal fornix?

A

The exocervix, which protrudes into the vagina, is surrounded by vaginal fornix.

71
Q

Describe the vagina.

A

The vagina is about 8cm long and the thick lamina propia, which is filled with elastic fibers, accounts for vaginal distensibility.

The vagina also has nonkeratinized stratified squamous epithelium, which is characterized by pale epithelial cell cytoplasm. This pale epithelium has variable amounts of glycogen. Near the time of ovulation, estrogen stimulates an increased glycogen content. When the cells are shed, they discharge glycogen into the vaginal lumen.

72
Q

Where does vaginal lymph drain? What artery supplies the vagina?

A

Internal iliac lymph nodes

Vaginal artery

73
Q

How are sensations from the vagina conveyed?

A

superior half: visceral afferent fibers of the pelvic splanchnic nerves
inferior half: somatic sensory fibers of the pudendal nerve

74
Q

How does pain relief during childbirth differ after local pudendal or ilioinguinal nerve blocks?

A

Local pudendal: anesthetizes the whole perineal area

Ilioinguinal nerve: anterior perineal part only

75
Q

What does rupture of the cloacal membrane do?

A

It enables ectoderm and endoderm to jointly line the anal canal.

76
Q

What does the anal fold form?

A

it forms the epidermal lined anus

77
Q

What happens at the anorectal junction?

A

The rectum perforates the levator ani to join the anal canal.

Superior portion of the anal canal: anal columns formed by permanent longitudinal folds of the endoderm -derived mucosa

Inferior ends of anal columns: mark the location of the pectinate line

78
Q

What arteries supply the anal canal above and below the pectinate line?

A

above the pectinate line: hind-gut derived portion supplied by the superior rectal artery

below the pectinate line: ectoderm-derived portion supplied by the inferior rectal artery which is a branch of the internal pudendal artery

79
Q

How is the anal canal innervated?

A

Hind gut-derived portion of the anal canal: below the pelvic pain line and when distended visceral sensory fibers from DRG at S2-S4 refer dull diffuse pain to the perineum and posterior thighs.

Inferior rectal nerve (branch of the pudendal nerve) supplies the anal canal below the pectinate line; it is locally sensitive to pain, touch and temperature

80
Q

Differentiate venous blood and lymph drainage between above and below the pectinate line.

A

venous blood:
above –> hepatic portal vein
below –> IVC

lymph drainage
above –> internal iliac lymph nodes
below –> superficial inguinal lymph nodes

81
Q

What creates internal hemorrhoids? external hemorrhoids?

A

internal –> distension of veins in the lamina propia above the pectinate line

external –> distension of veins in the lamina propia below the pectinate line

82
Q

What are predisposing factors for hemorrhoids and why can external hemorrhoids be painful while internal hemorrhoids are painless?

A

Predisposing factors: pregnancy, chronic constipation, and prolonged toilet sitting and strainging and any disorder that impedes venous return, including increased intra-abdominal pressure.

Anal canal superior to the pectinate line = visceral and is innervated by visceral afferent pain fibers so painless. inferior to the pectinate line, the anal canal is somatic and supplied by the inferior anal nerves containing somatic sensory fibers. It is sensitive to painful stimuli.

83
Q

What happens to the epithelium and muscle above and below the pectinate line?

A

above: endoderm derived simple columnar epithelium; inner circular smooth muscular layer of the muscularis externa thickens to form the involuntary internal anal sphincter
below: ectoderm-derived nonkeratinized stratified squamous epithelium; circular layer of skeletal muscle forms the external anal sphincter just superior to the anus

84
Q

What nerves maintain tonic contraction of the internal anal sphincter?

A

Lumbar splanchnic nerves that accompany branches of the superior rectal artery

85
Q

What do the pelvic splanchnic nerves do? What about inferior rectal nerve? Spinal nerve S4?

A

Distension of the rectal ampulla activates the pelvic splanchnic nerves

pelvic splanchnic nerves –> peristaltic contraction of the rectum and anal canal is reflexively invoked and tonus of the internal anal sphincter is reflectively inhibited

inferior rectal nerve –> voluntary contraction of the external anal sphincter for fecal continence

spinal nerve S4 –> voluntary contraction of puborectalis muscle for fecal continence