Abx in Systemic Fungal Infections

Question 1

Fungi are what, with what, can produce what?

Answer 1

Eukaryotic
Rigid cell wall composed of chitin (B1,3-D-Glucan) which doesn’t stain
Ergosterol instead of cholesterol
Can produce Spores

Question 2

Yeast are?

Answer 2

Unicellular

Pathogenic- Invades the hose

Question 3

Molds are?

Answer 3

Multicellular with branching

Free-living within the environment

Question 4

Asexual form is called?

Answer 4

Cryptococcus

Question 5

Infectious form is called?

Answer 5

Filobasidiella

Question 6

Three most common species of systemic infection?

Answer 6

Candida
Cryptococcus
Aspergillus

Question 7

Amphotericin B MOA

Answer 7

Binds to membrane via ergosterol and forms pores

Question 8

Amphotericin B ADME

Answer 8

IV only
Hepatic Excretion
Can cause development of renal problems

Question 9

Amphotericin B ADR

Answer 9

Nephro

Decrease K and Mg

Question 10

Amphotericin B Spectrum

Answer 10

Fungal and Aspergillis

Question 11

Flucytosine (5-FC) MOA

Answer 11

Resembles Cytosine
5-FUTP disrupts RNA and protein synthesis
5-FdUMP inhibits thymidylate synthetase (DNA)

Question 12

5-FC Spectrum

Answer 12

Yeast (Cryptococcus and Candida)

Question 13

5-FC ADME

Answer 13

Synergistic with Amp B

CSF

Question 14

5-FC ADR

Answer 14

Bone marrow Suppression

Hepatic dysfunction

Question 15

Imidazoles

Answer 15

2 Nitrogens

Question 16

Triazoles

Answer 16

3 Nitrogens
Fluconazole, itraconazole, vori, posa
Preferred

Question 17

Azoles MOA

Answer 17

Block P450 dependent synthesis of Ergosterol

Lanosterol -X-> Ergosterol

Question 18

Azoles Human Actions

Answer 18

Inhibit gonadal and adrenal steroid synthesis (decreased testosterone)

Question 19

Azole Spectrum

Answer 19

Candida
Crypto
Aspergillus

Question 20

Fluconazole target? Other?

Answer 20

Crypto
Coccidio
Renal
CNS

Question 21

Voriconazole target?

Answer 21

Aspergillus
CNS
Food decreases absorption

Question 22

Posaconazole target?

Answer 22

Zygomycetes
Little cyp
Oral only

Question 23

Azole ADR

Answer 23

CV
Hepato
Visual/Hallucinations

Question 24

Echinocandins MOA

Answer 24

Inhibit B(1,3)-D-glucan (cell wall component)

Question 25

Echinocandins Spectrum

Answer 25

Aspergillus
Systemic Candia
NOT cryptococcus

Question 26

Echinocandins ADME

Answer 26

IV only

Renal and Hepatic

Question 27

Echinocandins ADR

Answer 27

Infusion site

Altered liver/renal test

Question 28

Griseofulvin MOA

Answer 28

Microtubules - disrupt mitosis

Question 29

Terbinafine MOA and other

Answer 29

Lamsil

Squalene -X-> Lanosterol (decrease ergosterol production)