Invasive Fungal Infections

Question 1

Endemic Mycoses

Answer 1

Histoplasmosis
Blastomycosis
Coccidiodomycosis

Question 2

Opportunistic Mycoses

Answer 2

Candidasis
Cryptococcosis
Aspergillosis

Question 3

RF for Fungal Infections

Answer 3

Organ or bone marrow transplant
Cytotoxic chemotherapy
Indwelling catheter, burns, trauma
Broad Spectrum Abx

Question 4

Candida is acquired from?

Answer 4

GI tract

Catheter

Question 5

Immunosuppressed RF for invasive candidiasis

Answer 5

Neutropenia
Lymphoreticular or Hematologic malignancies
Uncontrolled Diabetes
Corticosteroids
Agents

Question 6

Other RF for invasive candidiasis

Answer 6

CV catheter
Total Parenteral nutrition (TPN)
Extensive surgery
Burns
Renal failure, dialysis
Abx
Prior infection

Question 7

Candida Lab Testing

Answer 7

Culture
Germ tube (within 1-2h)
PNA or FISH
Serologic

Question 8

Echinocandin Drugs

Answer 8

Capsofungin
Micafungin
Anidala IV

Question 9

Resistant bugs?

Answer 9

Krusei
Glabrata (overcome with high dose)

Question 10

Other bugs

Answer 10

Tropicalis

Parapsilosis

Question 11

Fluconazole dose

Answer 11

6 mg for C. albicans, C. tropicalis, C. parapsilosis,

12 mg for C. glabrata

Question 12

Itra and Vori have activity against?

Answer 12

C. glabrata and C. krusei

Question 13

Echinocandins have activity against

Answer 13

C. glabrata and C. krusei

NOT parapsilosis

Question 14

Amp B has activity againsts

Answer 14

Candida

Question 15

Aspergillosis Pathogenic species

Answer 15

Fumigatus
Flavus
Niger

Question 16

Aspergillosis infection via?

Answer 16

Inhalation + impaired host defenses

Question 17

RF for aspergillosis?

Answer 17

Prolonged neutropenia
Steroids
Cytotoxic agents
Abx

Question 18

RF for Cryptococcus

Answer 18

HIV infection
Lymphoproliferative disorders
Sarcoidosis
Steroids

Question 19

Histoplasmosis Endemic to

Answer 19

Ohio and Mississippi River Valley

Question 20

Blastomycosis endemic to?

Answer 20

Ohio and Mississippi River Valley

Great Lakes

Question 21

Chronic Pulmonary Blastomycosis

Answer 21

Weight loss
Night sweats
Thought to have TB

Question 22

Coccidiodomycosis endemic to?

Answer 22

California to Texas

Question 23

RF for Severe, disseminated coccidiodomycosis

Answer 23

Filipino
Prego
Immunecompromised
Male
Neonate
AB or B blood type

Question 24

Chronic Persistent Pneumonia

Answer 24

Greater than 6 weeks of primary disease
Coughing up blood
Pulmonary scarring

Question 25

Valley Fever

Answer 25

Red nodules and red multiforme

Rash

Question 26

Disseminated disease

Answer 26

Skin, lymph nodes, bone, meninges