Transfusion Medicine

Question 1

For all _____, donor and recipient cells are typed for ABO and Rh(D).

Answer 1

transfusions

Question 1

What reaction causes bronchospasm and large airway response; is usu in IgA deficient individuals; cause unk?

Answer 1

anaphylactic rxn

Question 2

What is H antigen + fucose + D-galactose?

Answer 2

type B

Question 2

What is the Rh rule of thumb?

Answer 2

D > > C, E, ē, c > others

Question 2

What reaction is due to alloantibody production and the slow destruction of the sensitizing RBCs and has very few signs and symptoms?

Answer 2

delayed hemolytic rxn

Question 3

What is a delayed hemolytic reaction?

Answer 3

alloantibody production and the slow destruction of the sensitizing RBCs; very few signs and symptoms

Question 4

What is type B blood?

Answer 4

H antigen + fucose + D-galactose

Question 4

What is an immediate hemolytic transfusion reaction?

Answer 4

transfusion of incompatible blood products; activation of complement and intravascular hemolysis can lead to shock, renal failure, or DIC

Question 5

What are the 2 most common adverse events in blood transfusions, and what are their treatments?

Answer 5

1) febrile non-hemolytic transfusion rxn (Tylenol) 2) mild allergic rxn (Benadryl)

Question 7

What are the human RBC alloantigens and what are they made of?

Answer 7

A, B, O, or AB; polysaccharides

Question 8

What are alloantigens?

Answer 8

differences on the surfaces of RBCs that change their biochemical and immunology but not their functionality

Question 9

What reaction is due to volume/fluid overload?

Answer 9

Transfusion Related Circulatory Overload (TACO)

Question 10

What is Transfusion Related Circulatory Overload (TACO)?

Answer 10

volume/fluid overload

Question 11

What is acute lung injury w/i 6 hours of transfusion?

Answer 11

Transfusion Related Lung Injury (TRALI)

Question 12

What is an anaphylactic reaction?

Answer 12

bronchospasm and large airway response; usu in IgA deficient individuals; cause unk

Question 14

What is type A blood?

Answer 14

H antigen + fucose + N-acetylgalactosamine

Question 16

What is the basic sugar chain on the RBC membrane?

Answer 16

H antigen

Question 17

What is apheresis?

Answer 17

automated machines take anticoagulated blood from the donor, separate out one or more components by centrifugation and buoyant density, and return the unused components to the donor

Question 18

What is type O blood?

Answer 18

H antigen + fucose

Question 20

What reaction is due to transfusion of incompatible blood products and leads to the activation of complement and intravascular hemolysis can lead to shock, renal failure, or DIC?

Answer 20

immediate hemolytic transfusion rxn

Question 21

What is Transfusion Related Lung Injury (TRALI)?

Answer 21

acute lung injury w/i 6 hours of transfusion

Question 22

What is the process of using automated machines to take anticoagulated blood from the donor, separate out one or more components by centrifugation and buoyant density, and return the unused components to the donor called?

Answer 22

apheresis

Question 23

For all transfusions, donor and recipient cells are typed for ___ and ____.

Answer 23

ABO; Rh(D)

Question 24

What is H antigen + fucose + N-acetylgalactosamine?

Answer 24

type A

Question 25

What is H antigen + fucose?

Answer 25

type O