Inflammation Flashcards
(56 cards)
What is frustrated phagocytosis?
attempts to phagocytose something that is too large
Where is squamous epi found?
skin and esophagus
How does a post-MI heart look 7-10 days after the attack?
maximally yellow-tan and soft; with depressed red-tan margins
What cause edema/tumor in acute injury?
outward flow of ions and water
What helps the leukocyte stick to the endothelium and diapedes?
integrins and intracellular adhesion molecules
What occurs during complete resolution?
macrophages clean up necrotic debris; tissue regenerates; lymphatic drainage clears edema
What perforates holes in the microbial membrane?
defensin
What happens to the surrounding interstitial tissue in acute inflammation?
increasing in osmotic pressure- more water follows- swelling occurs
What happens when the body can’t overcome the infection and has to wall it off?
an abscess forms; chronic inflammation
How does a post-MI heart look 4-12 hours after the attack?
occasional dark mottling
What are Kupffer cells?
macs in the liver
What is exudate?
protein rich content and cells; >1.02 g/mL; low glucose
How does the leukocyte neutralize the bacteria?
phagocytosis, uses degranulation of lysosomal enzymes and defensins
What is Chediak-Higashi Syndrome?
a defect in chemotaxis and lysosomal degranulation into phagosomes
How does a post-MI heart look during the first 4 hours after the attack?
no change
What are happens to the vasculature in acute inflammation?
transient vasoconstriction, then vasodilation; increased hydrostatic pressure in vessel wall
What kinds of cells are the infrastructure cells?
1) fibroblasts 2) endothelial cells
What cause leukocytes to roll and adhere to the vasculature first?
selectins
Which cell has a bi-lobed nucleus but also has pink-staining granules?
eosinophils
How does a leukocyte find the bacterial infection?
chemotaxis
How do leukocytes move?
by extending pseudopods
Why do the exudate and transudate exit the area in acute inflammation?
to decrease the pressure on the expanding vessel
What is the basement membrane composed of?
collagen
What are the 3 major things that happen in acute inflammation?
1) vasodilation 2) plasma proteins leave microvasculature 3) emigration of leukocyte
