Lec 18 Liver Flashcards
1
Q
What is the function of hepatocytes?
A
key metabolic cell in liver
most abundant cell
2
Q
What is function of kupffer cells?
A
liver-specific macrophages
3
Q
What is the function of hepatic stellate cells in health vs injured liver?
A
in healthy liver: stores vitamin A
becomes activated into myofibroblast-like cell in liver injury = main source of scar in hepatic fibrosis
4
Q
What is unique about the structure of sinusoidal endothelial cells?
A
they are fenestrated = have pores
5
Q
What does high AST/ALT suggest?
A
injury to hepatocytes
6
Q
What are 4 complications of cirrhosis?
A
- hepatic encephalopathy
- ascites
- portal hypertension
- hepatorenal syndrome
7
Q
What does high alkaline phosphatase suggest?
A
injury to bile ducts
8
Q
What are 6 signs of chronic liver disease?
A
- scleral icterus
- spider angioma
- glossitis
- palmar erythema
- digital clubbing
- gynecomastia
9
Q
What is the most common cause of spider angiomata?
A
pregnancy
