Lec 25 Liver Path 2

Question 1

What is target antigen in primary biliary cirrhosis?

Answer 1

pyruvate dehydrogenase complex on bile duct cells

Question 2

What do you see grossly in progressed primary biliary cirrhosis?

Answer 2

live looks green

Question 3

How do you diagnose primary sclerosing cholangitis histologically?

Answer 3

by the onion skin fibrosi and narrowing of bile duct lumen

dilation of preserved segments

Question 4

What do you see in liver with hereditary hemochromatosis?

Answer 4

brown/bronze liver
very little inflammation
see iron on prussian blue stain

Question 5

Is wilsons disease assocaited wtih increased risk of hepatocellular carcinoma?

Answer 5

nope!

Question 6

What stain should you use in wilson disease?

Answer 6

rhodanine stain

Question 7

What is genetics of alpha 1 antitrypsin deficiency?

Answer 7

autsosomal recessive on chromosome 14

Question 8

What do you see histologically with alpha 1 antitrypsin deficiency?

Answer 8

round to oval cytoopalsmic globular inclusions in periportal hepatocytes

Question 9

What stain do youuse for alpha 1 antitrypsin deficiency?

Answer 9

PAS-D stain

Question 10

What is histology of hepatic adenoma?

Answer 10

• looks like normal hepatocytes

- absent portal tracts, central venules

Question 11

What is risk factor for hepatic adenoma?

Answer 11

oral contraceptive use

Question 12

What is a hepatic adenoma?

Answer 12

benign liver tumor

solitary, well demarcated, encapsulated

Question 13

What is focal nodular hyperplasia?

Answer 13

benign hepatocellular lesion; seen in women in 30s-40s

Question 14

What are some associated wtih focal nodular hyperplasia?

Answer 14

hemangioma or hepatocellular adenomas

Question 15

Is FNH malignant?

Answer 15

nope –> can not transform into HCC

Question 16

What major feature can you use to distinguish focal nodular hyperplasia?

Answer 16

central scar = abnormal vasculature

Question 17

What is nodular regenerative hyperplasia?

Answer 17

looks like cirrhosis; can cause non-cirrhotic portal hypertension
occurs w/ collagen vascular disease

Question 18

What are major sources of malignant liver tumors?

Answer 18

• colon
• pancreas
• lung

Question 19

What do you see on histology in hepatocellular carcinoma?

Answer 19

• heterogeneous
• similar to benign hepatocytes
• no portal tracts

Question 20

What is pathology of cholagniocarcinoma?

Answer 20

adenocarcinoma with desmoplastic reaction

Question 21

What are some post transplant complications?

Answer 21

• DM
• hyperlipidemia
• obesity

Question 22

What is most common cause of death post liver transplant?

Answer 22

cardiovascular related

Question 23

When do you see acute cellular rejection?

Answer 23

within initial weeks

Question 24

What are findings of acute cellular rejection?

Answer 24

• high liver enzymes
• CD4 and CD8 cells
• mixed cellular infiltrate