Ob: teratogenic agents

Question 1

fetal renal tubular dysplasia and neonatal renal failure
oligohydramnios
IUGR
lack of cranial ossification

Answer 1

ACEIs

Question 2

growth restriction before and after birth
mental retardation
midfacial hypoplasia
renal and cardiac defects

Answer 2

alcohol

-consumption of > 6 drinks per day is an assoc 40% risk of fetal alcohol syndrome

Question 3

virilization of females

advanced genital development in males

Answer 3

androgens

Question 4

neural tube defects
fingernail hypoplasia
microcephaly
developmental delay
IUGR

Answer 4

carbamazepine

Question 5

bowel atresias
congenital malformation of the heart, limbs, face and GU tract
microcephaly
IUGR
cerebral infaarctions

Answer 5

cocaine

Question 6

clear cell adenocarcinoma of the vagina or cervix
vaginal adenosis
abnormalities of the cervix and uterus or testes
possible infertility

Answer 6

diethylstilbestrol (DES)

Question 7

increase spontaneous abortion rate

stillbirths

Answer 7

lead

Question 8

congenital heart disease (Ebstein anomaly)

Answer 8

lithium

Question 9

increase spontaneous abortion rate

Answer 9

methotrexate

Question 10

cerebral atrophy
michrocephaly
mental retardation
spasticity
seizures
blindness

Answer 10

organic mercury

Question 11

IUGR
mental retardation
microcephaly
dysmorphic craniofacial features
cardiac defects
fingernail hypoplasia

Answer 11

phenytoin

Question 12

microcephaly

mental retardation

Answer 12

radiation

-medical diagnostic radiation delivering < 0.05 Gy to the fetus has no teratogenic risk

Question 13

hearing loss

CN VIII damage

Answer 13

streptomycin

kanamycin

Question 14

permanent yellow-brown discoloration of deciduous teeth

hypoplasia of tooth enamel

Answer 14

tetracycline

Question 15

bilateral limb deficiencies
anotia and microtia
cardiac and GI anomalies

Answer 15

thalidomide

Question 16

cleft lip or cleft palate
cardiac defects
microcephaly
mental retardation

Answer 16

trimethadione

paramethadione

Question 17

neural tube defects (spina bifida)

minor craniofacial defects

Answer 17

valproic acid

Question 18

increase spontaneous abortion rate
microtia
thymic agenesis
cardiovascular defects
craniofacial dysmorphism
microphthalmia
cleft lip or cleft palate
mental retardation

Answer 18

Vit A and derivatives

Question 19

nasal hypoplasia and stippled bone epiphyses
developmental delay
IUGR
opthalmologic abnormalities

Answer 19

warfarin