Antimicrobic Agents (pt4)

Question 1

Which Inhibitor of cell wall synthesis binds onto the cross-link peptide, so that the link cannot be completed and peptidoglycan polymer cannot elongate

Answer 1

Vancomycin

Question 2

Which Inhibitor of cell wall synthesis blocks phospholipid carrier that helps carry subunits of peptidoglycan across membrane to cell wall

Answer 2

Bacitracin

Question 3

Which Inhibitor of cell wall synthesis inhibits formation of mycolic acid in cell walls of mycobacterium

Answer 3

Isoniazid

Question 4

Which antimicrobic principle inhibits accurate translation of mRNA or polypeptide chain formation at the bacterial ribosome?

Answer 4

Inhibitors of protein synthesis

Question 5

Which Inhibitors of protein synthesis inhibit translation by binding to 30S ribosomal protein causing misreading of mRNA and incomplete synthesis of protein molecules?

Answer 5

Aminoglycosides

Question 6

Which Inhibitors of protein synthesis inhibits translation into polypeptides (proteins) by blocking binding of tRNA to the 30S ribosome-mRNA? complex

Answer 6

Tetracyclines

Question 7

Which Inhibitors of protein synthesis inhibits the polypeptide elongation steps in translation by binding to 50S ribosome subunit?

Answer 7

Chloramphenicol

Question 8

Which antimicrobic principle disrupts functional integrity of cytoplasmic membrane, allowing nucleotides and proteins to escape?

Answer 8

Inhibitors of cell membrane function

Question 9

What are the three types of Inhibitors of protein synthesis ?

Answer 9

Aminoglycosides, Tetracyclines, and Chloramphenicol

Question 10

What are the two types of Inhibitors of cell membrane function?

Answer 10

Polymyxins and Amphotericin B

Question 11

Which Inhibitor of cell membrane function is active against gram-negatives, but nephrotoxicity limits them to external use?

Answer 11

Polymyxins

Question 12

Which Inhibitor of cell membrane function is an antifungal and binds with ergosterol in fungal membranes?

Answer 12

Amphotericin B

Question 13

Which antimicrobic principle has competitive inhibition of essential nucleic acid precursor or binds essential enzyme?

Answer 13

Inhibitors of nucleic acid synthesis

Question 14

Which antimicrobic inhibitor do these fall under?

Quinolones and Fluoroquinolones

Rifampin

Metronidazole

Nucleoside analogues

Flucytosine, 5-fluorocytosine

Answer 14

Inhibitors of nucleic acid synthesis

Question 15

Which Inhibitors of nucleic acid synthesis inhibit bacterial DNA gyrase?

Answer 15

Quinolones and Fluoroquinolones

Question 16

Which Inhibitors of nucleic acid synthesis inhibits transcription by binding to RNA polymerase and inhibiting initiation of mRNA synthesis

Answer 16

Rifampin

Question 17

Which Inhibitors of nucleic acid synthesis causes breakage of microbial DNA?

Answer 17

Metronidazole

Question 18

Which Inhibitors of nucleic acid synthesis inhibit DNA or RNA synthesis by altering their composition using nucleic acid analogues

Answer 18

Nucleoside analogues

Question 19

Which Inhibitors of nucleic acid synthesis incorporates into fungal RNA and interferes with DNA and protein synthesis?

Answer 19

Flucytosine, 5-fluorocytosine