Antineoplastics

Question 1

Temozolomide
Mechanism:
Ability to cross BBB (how):
Cell cycle specific?

Answer 1

Alkylating agent

easily crosses BBB (small, lipophilic, NO EFFLUX)

cell cycle nonspecific

Question 2

Vincristine
Mechanism:
Ability to cross BBB (how):
Cell cycle specific?

Answer 2

Inhibits assembly of microtubules

crosses BBB (NOT small, lipophilic, EFFLUXED)

CCS: yes, metaphase

Question 3

Carmustine (BCNU)
Mechanism:
Ability to cross BBB (how):
Cell cycle specific?

Answer 3

Alkylating agent

poorly crosses BBB

NOT cell cycle specific

Question 4

Etoposide
Mechanism:
Ability to cross BBB (how):
Cell cycle specific?

Answer 4

Binds with Topo II and cause DNA strand breaks

crosses BBB

CCS late S phase

Question 5

Amphotericin B
Class:
Mechanism:
Ability to cross BBB (how):

Answer 5

Antifungal

binds ergosterol

yes, crosses BBB

Question 6

Fluconazole
Class:
Mech:
Crosses BBB?

Answer 6

Antifungal

inhibits ergosterol synth via fungal cyt P 450

does NOT cross BBB

Question 7

Dexamethasone use in chemo:

Answer 7

Reduce swelling and also an anti emetic.