Mechanisms of Acute Neuronal Injury

Question 0

Cytotoxic edema

Answer 0

Occurs when ATP stores are deplete and membrane ionic permeability is too high

-Neuronal ATP dependent upon continuous supply of O2 and glucose

Question 1

NMDA receptor characteristics

Answer 1

1. Activation requires glycine
2. Dually gated by glutamate and membrane potential
3. Permeable to Ca2+
   - Also contains a Mg2+ binding site that blocks ion flow when bound