Pestana Transplantation

Question 1

What is the ONLY absolute contraindication for organ donation?

Answer 1

Positive HIV status

Question 2

Pathophysiology of hyperacute rejection? Prevention?

Answer 2

Vascular thrombosis to the organ by preformed antibodies within minutes of implantation. Never happens because all organs undergo ABO matching and Lymphocytotoxic crossmatching.

Question 3

Signs of acute liver rejection? What must be ruled out? Treatment?

Answer 3

Rising GGT, alkaline phosphatase, and bilirubin. Rule out biliary obstruction by ultrasound and vascular thrombosis by Doppler.

Question 4

How are heart transplants monitored to see if they develop acute rejection?

Answer 4

Ventricular biopsies of the jugular, superior vena cava, and right atrium at set intervals.

Question 5

Timeline and Treatment of acute rejection?

Answer 5

5 days to 3 months. Steroid bolus.

Question 6

Timeline and Treatment of chronic rejection?

Answer 6

Years after transplant. No real therapy, just slow decline of organ function.