3.4 Mass Transport Flashcards
(91 cards)
Structure of haemoglobin
Globular, water soluble. Consists of four polypeptide chains, each carrying a haem group (quaternary structure).
Role of haemoglobin
Present in red blood cells. Oxygen molecules bind to the haem groups and are carried around the body to where they are needed in respiring tissues.
3 factors affecting oxygen-haemoglobin binding
- Partial pressure/concentration of oxygen.
- Partial pressure/concentration of carbon dioxide.
- Saturation of haemoglobin with oxygen.
What happens to the affinity of haemoglobin for oxygen as partial pressure of oxygen increases?
The affinity of haemoglobin for oxygen increases.
What occurs when the partial pressure of oxygen is low?
Oxygen is released from haemoglobin.
What is the relationship between partial pressure of oxygen and how tightly oxygen binds to haemoglobin?
As partial pressure of oxygen increases, oxygen binds more tightly to haemoglobin.
What happens to haemoglobin as the partial pressure of carbon dioxide increases?
Haemoglobin changes shape.
How does increased partial pressure of carbon dioxide affect the acidity of the conditions?
It causes the conditions to become acidic.
What is the effect of increased acidity on the affinity of haemoglobin for oxygen?
The affinity of haemoglobin for oxygen decreases.
What is released from haemoglobin as a result of increased partial pressure of carbon dioxide?
Oxygen is released from haemoglobin.
What is the phenomenon called when increased carbon dioxide partial pressure leads to decreased oxygen affinity in haemoglobin?
The Bohr effect.
What is the effect of the first oxygen molecule binding to hemoglobin?
It is hard for the first oxygen molecule to bind.
What is positive cooperativity in hemoglobin?
Once the first oxygen molecule binds, it changes the shape of hemoglobin to make it easier for the second and third molecules to bind.
Why is it slightly harder for the fourth oxygen molecule to bind to hemoglobin?
There is a low chance of finding a binding site.
Why oxygen binds to haemoglobin in the lungs
- Partial pressure of oxygen is high.
- Low concentration of carbon dioxide in the lungs, so affinity is high.
- Positive cooperativity (after the first oxygen molecule binds, binding of subsequent molecules is easier).
Why oxygen is released from haemoglobin in respiring tissues
- Partial pressure of oxygen is low.
- High concentration of carbon dioxide in respiring tissues, so affinity decreases.
What do oxyhaemoglobin dissociation curves plot?
Saturation of haemoglobin with oxygen (in %) against partial pressure of oxygen (in kPa).
What does a curve further to the left on an oxyhaemoglobin dissociation curve indicate?
Haemoglobin has a higher affinity for oxygen.
Effect of carbon dioxide on oxyhaemoglobin dissociation curve
Curve shifts to the right because haemoglobin’s affinity for oxygen has decreased.
What is the suitable medium for transport in a mammalian circulatory system?
Water-based to allow substances to dissolve.
What organ is responsible for moving the transport medium in a mammalian circulatory system?
The heart.
What is the purpose of valves in a mammalian circulatory system?
To control flow so it remains unidirectional.
What are the characteristics of the atria in the heart?
The atria are thin-walled and elastic, allowing them to stretch when filled with blood.
What are the characteristics of the ventricles in the heart?
The ventricles have thick muscular walls that pump blood under high pressure.