antibiotics 1 antimetabolites

Question 1

sulphonamides what do they do

Answer 1

create a false product
structural analogue of pAB
competes with the enzyme dihydropteroate synthetase

Question 2

what do sulphonamides do when they bind

and why

Answer 2

cant bind glutamate

because of the -SO2NH2

Question 3

dapsone what it used for and what does it do

Answer 3

related to sulphonamide reaction
creates false product
for leprosy

Question 4

p- amino salicylic acid what is it used for

Answer 4

selective agent to treat tuberculosis

Question 5

what do other antimetabolites target

Answer 5

the synthesis of folate

inhibitors of dihydrofolate reductase

Question 6

what drug inhibits dihydrofolate reductase

Answer 6

methotrexate

Question 7

methotrexate where is it used

Answer 7

anti cancer drug

tumour cells replicate faster so they rely on this pathway more the our other cells

Question 8

what is a folate antagonist

Answer 8

trimethoprim

Question 9

trimethoprim what is it

whats its selectivity

Answer 9

bacterostatic
folate antagonist
7000 fold selectivity forbacterial enzyme

Question 10

what is trimethoprim used in

Answer 10

used in combo with suphamethoxazole T;S 1:20

Question 11

pyrimethamine what is it used for

Answer 11

malaria

not toxic to bacteria but to plasmodia