protein synthesis chloramphenicol Flashcards
1
Q
what kind of antibiotic is it bacter-
what does it inhibit
A
bacteriostatic
inhibits 50s by inhibiting peptidyl transferase (elongation)
2
Q
how does it inhibit peptidyl transferase
A
inhibits AA elongation by stopping the bond formation
inhibits peptidyl transferase binding to A2451 and A2452 residues in 23s rRNA of 50s
3
Q
selective toxicity
A
does not bind to 80s
4
Q
resistance
A
chloramphenicol acetyl transferase-
causing a side group acetylation
5
Q
side effects what are they
A
gray baby syndrome
reversible anaemia
6
Q
gray baby syndrome what is it
A
secreted by Glucuronidation (made water soluble by adding sugar)
not developed in neonates
7
Q
reversible anaemia
A
bone marrow depression
8
Q
where can you use this drug
A
eye infections and life threatening conditions
