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Microbiology Block 3 > Facts about Pathogenic Escherichia coli: > Flashcards

Facts about Pathogenic Escherichia coli: Flashcards

1
Q

what important common features does pathogenic Escherichia coli strains have?

A
  • Lactose Fermenter (pink on MacConkey)
  • Strict pathogens cause GI infections
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2
Q

all strains will be identified using what E. coli biology facts?

A

Gram negative bacilli

Motile

Lactose fermenter

Oxidase negative

Catalase +

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3
Q

what are the 4 clinical diseases Escherichia coli causes?

A

1) Entero Toxin E. coli (ETEC)
2) Entero Pathogenic E. coli (EPEC)
3) Entero-Invasive E. coli (EIEC)
4) Entero-Hemorragic E. coli (EHEC)

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4
Q

how does EPEC spread?

A

fecal-oral in developing countries

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5
Q

how does ETEC spread?

A

fecal-oral in developing countries

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6
Q

how does EIEC spread?

A

fecal-oral in developing countries

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7
Q

how does EHEC spread?

A

through fecal-oral found in beef or produce

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8
Q

In ETEC, what is another name for entero-toxigenic E. coli?

A

traveler’s diarrhea

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9
Q

what is another name for ETEC, other than traveler’s diarrhea?

A

Montezuma’s Revenge

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10
Q

what does Entero-toxigenic E. coli do?

A

it attaches to the small intestine using fimbreae

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11
Q

what 2 entero toxins will cause the symptoms seen with ETEC?

A
  1. ​LT (heat-liable toxin)
  2. ST (heat-stable toxin)
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12
Q

what is the presentation of Entero-toxic E.coli?

A

self-resolving profuse watery secretory diarrhea without fever

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13
Q

how does the LT toxin from ETEC cause diarrhea?

A

it increases levels fo cAMP through activation of adenylyl cyclase.

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14
Q

how does the ST toxin cause profuse watery diarrhea in ETEC?

A

it activates guanylate cyclase and increases cGMP

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15
Q

what is another name for EPEC (entero-pathogenic e.coli)?

A

Pediatric diarrhea

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16
Q

where is EPEC common?

A

in developing countries

17
Q

what is the pathogenic mechanism of action in EPEC?

A

EPEC attaches to small intestine using T3SS (attaching and effacing lesions and kills microvilli.

leads to reduced absorption of water leading to symptoms

18
Q

how does EPEC present clinically?

A

self-resolving secretory watery diarrhea without fever

19
Q

what is another name for EIEC?

A

invasive diarrhea

20
Q

what is the pathological presentation of EIEC?

A

EIEC attaches to colon using fimbriae and it rockets from cell to cell causing severe destrion of epithelial layer and releases hemolysin killing RBC’s

21
Q

what is the clinical presentation fo EIEC?

A

dysentery (low volume bloody stool with WBC present) with high fever

22
Q

what is another name for EHEC?

A

hemorrhaging diarrhea

23
Q

outbreaks in the US is due to what?

A

bacteria uses cattle as a reservoir

24
Q

what is the pathological presentation of EHEC?

A

EHEC forms A/E lesions in the small intestine causing the diarrhea, then is uses shiga-toxin to destroy endothelial cells leading to the blood in the stool

25
Q

the shiga toxin found in EHEC, can spread to what other organ endothelial tissue?

A

kidney

26
Q

what is the clinical presentation of EHEC?

A

watery diarrhea followed by profuse bloody diarrhea without fever or WBC

27
Q

what can EHEC lead to after a while?

A

Hemolytic Uremic Syndrome

28
Q

what is EHEC serotype O157:H7 named after?

A

named based on LPS O and H antigen on its flagella

29
Q

is EHEC invasive? how is your answer related to fever?

A

no, which is why fever is most often absent

30
Q

what symptom is shiga-toxin responsible for?

A

it is responsible for the destruction of endothelial cells which leads to hemorrhaging

31
Q

what does shiga toxin do to kill intestinal villi?

A

cleaves hosts 28s RNA ribosome

32
Q

on who is hemolytic uremic syndrome most common?

A

5 years or less on TMP/SMX antibiotics

33
Q

what is the clinical presentation for hemolytic uremic syndrome?

A

thrombocytopenia

Microangiopathic hemolytic anemia

Neurological manifestations

34
Q

in EHEC, where will it not ferment? colonies will look how?

A

Sorbitol-MacConkey agar (S-Mac), colonies look white

35
Q

can other e.coli ferment Sorbitol-MacConkey agar (S-Mac)?

A

yes

36
Q

what e.coli is this?

A

EHEC

37
Q

on what food is EHEC mostly found?

A

burgers

Microbiology Block 3 (39 decks)

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