4.1 Intro to Liver disease Flashcards
1
Q
What do hepatocytes synthesis?
A
Albumin Lipoproteins Coagulation factors (2,7,9,10) Glycogen Urea Bile salts Cholesterol
2
Q
What do hepatocytes excrete?
A
Bilirubin Bile salts Ammonia Alcohol Drugs Toxins
3
Q
What are the symptoms of acute hepatitis (hepatocellular necrosis)
A
Anorexia Lethargy Jaundice Biliruninuria Tender liver ALT > 10x
4
Q
Symptoms of cholestasis
A
Jaundice Biliruninuria Pale stools Malabrosption Pruritis
5
Q
What are the symptoms of liver failure with portal hypertension?
A
Ascites
Dilated abdominal veins
Muscle wasting
Fullness in left flank (splenomegaly)
6
Q
What are the features of compensated cirrhosis?
A
Jaundice Ascites Hepatic encephalopathy Impaired protein synthesis (coagulopathy) Catabolism: muscle wasting
7
Q
What LFTs indicate cholestasis?
A
ALP > 2x and ALP more than 3x ALT, raised GGT
8
Q
What LFTs indicate hepatocellular damage?
A
ALT > 2x and ALT more than 3x ALP
9
Q
What LFTs will you see in hepatitis?
A
ALT >2-5, GGT raised
10
Q
What LFTs will you see in cirrhosis
A
Low albumin, prolonged PT, low platelets
