arteri Flashcards
describe the structure and genome of arteriviridae
-enveloped, spherical-linear, positive sense, ssRNA. genomic RNA is infectious
t/f - arteriviridae persistent infections are rare
falsearteriviridae frequently establish persistent infections
arteriviridae replication takes place in the _____. virions are formed by budding into _______. they are released from the infected host cell by ______.
cytoplasm; the endoplasmic reticulum; exocytosis
what condition does arterivirus cause in horses?
Equine Viral Arteritis
how many serotypes does equine arterivirus have?
one
what is the reservoir for EVA (equine viral arteritis)?
carrier stallionsthese are stallions that are persistently infected (roughly 30-60% of the stallions which are infected)
how does lateral spread of EVA occur?
carrier stallion –> masturbation, fomites, personnel, teaser stallions –> uninfected stallion is infected30-60% of these stallions become persistently infected
how does venereal transmission of EVA work?
carrier stallion –> breeding (natural or artificial); raw or frozen semen –> uninfected mare is infected
t/f - there is no carrier state for EVA in mares
true. there is also no carrier state in geldings or foals <6 months.
what are the ways that EVA is transmitted horizontally?
aerosol/respiratoryfomitespersonnel
t/f - Spread by the respiratory route is the principal mode of dissemination of the EVA during the acute phase of infection
true
t/f - Transplacental transmission of EAV to fetus can occur in late gestation and may result in foal with congenitally acquired EAV infection
true
______ and ______ are the principal sites of EVA replication
macrophages and endothelial cells
main pathogenesis of EVA?
Damage to blood vessels leading to generalized edema and hemorrhage
