Antiarrhythmias

Question 1

pindolol

Answer 1

non selective
short half life
++ISA

Question 2

Propanolol

Answer 2

non selective
first developed
has sedative effect
can tx tremor

Question 3

acebuolol

Answer 3

selective
+ISA
tx pvc

Question 4

nebivolol

Answer 4

selective with ancillary properties
+++ ISA
Generates NO-> vasodilation
Tx pulmonary HTN

Question 5

sotalol

Answer 5

recurrent Afib and AFL

life threatening VTac

Question 6

verapamil

Answer 6

Ca channel blocker
slows conduction at AV node
more potent than diltiazem
tx MAT and ILVT
works well with beta blocker
pulmonary friendly

Question 7

diltiazem

Answer 7

Ca channel blocker, slows conduction at AV node
IV and PO available
works well with Betablocker

Question 8

quinidine

Answer 8

class Ia
cichona tree
Na channel blocker
use dependent
increases QT interval
tx brugada syndrome, early repolarization syndrome
AE: diarrhea, thrombocytopenia, hepatitis, lupus like syndrome, fatal arrythmias
metabolized by liver

Question 9

procainamide

Answer 9

class Ia 
bocks Na>K channels
tx acute afib, wolf-parkinsons-white syndrome, VT storm
AE rashes, myalgias, lupus like syndrome
renal metabolism

Question 10

disopyramide

Answer 10

class Ia
Na channel blocker
can increase conduction though nodes
tx A-fib, hypertorphic cardiomyopathy (women over 40 with atrial tachycardias and bradycardia)
AE anticholinergic (dry mouth, blurred vision, constipation, urinary retention
renal excretion

Question 11

lidocaine

Answer 11

class Ib
IV
narrow therapeutic range
used wit amiodarone or sotalol
AE neurotoxic
liver metabolism

Question 12

mexilitine

Answer 12

class Ib
“oral version of lidocaine”
used for transition from lidocaine (with amiodarone or sotalol)
tx automatic ventricular arrhythmias (ILVT, RVOT, LQT)
take with meals
AE GI irritation
liver metabolism

Question 13

propafenone

Answer 13

class Ic
Na channel blocker
use dependent
has some beta blocker properties
tx atiral arrhythmias for women
AE asthma issues, raynauds syndrome, can raise INR
liver metabolism

Question 14

flecainide

Answer 14

class Ic
Na channel blocker
use dependent
tx multiple arrythmias in "healthy people" (no CHF or CAD) and doesnt treat flutter
renal and hepatic metabolism

Question 15

sotalol

Answer 15

class III
K and beta blocker
tx afib, bt and VT storm in men on beta blocker
80 mg bid acts as beta blocker
renal metabolism

Question 16

dofetilide

Answer 16

class III
K bloker
tx afib, atrial tachys in healthy people
hospital admission required to start
many drug interactions

Question 17

amiodarone

Answer 17

class III
has Class I, II, III, Ca and beta blocker properties
best Afib tx
tx Vtac
AE predicable toxicity to lungs, thyroid, liver and retina; can raise INR
routinely check DLCO, liver enzymes, Ft4/tsh, eyes

Question 18

ranolazine

Answer 18

class III
developed for angina
Na, K and Ca blocker
decreases ventricular arrhythmias with ICD
with Dronedarone for afib

Question 19

Nadolol

Answer 19

non selective
long half life 12-24 hours
hydrophillic