Dr. French's Review Sesh

Question 1

How is LMWH monitored?

Answer 1

monitoring is not needed

Question 2

The fibrinolytic drugs end in -_____.

Answer 2

-teplase

Question 3

How does heparin work?

Answer 3

binds ATIII to inactivate IIa and Xa

Question 3

What is the antidote for Warfarin?

Answer 3

vitamin K

Question 3

_____ is Beta-1 selective.

Answer 3

Metoprolol

Question 3

You would not add a beta-blocker to pts already on ____.

Answer 3

a Ca++ blocker (Verapamil, diltiazem)

Question 4

Metoprolol is _____ selective.

Answer 4

Beta-1

Question 5

How is heparin monitored?

Answer 5

PTT

Question 6

Name 4 drugs a pt will be put on post-MI to improve long term prognosis and why.

Answer 6

1. antiplatelet (reduce thrombosis) 2. ACEI (prevent LV remodeling and endothelial cell dys) 3. statin (reduce LDL, reverse endo cell dys) 4. beta blocker (prevent ischemia, prevent arrhythmias)

Question 8

What do nitrates do to HR?

Answer 8

increase it

Question 10

What drugs relieve ischemic pain?

Answer 10

nitrates and morphine

Question 12

What is protamine?

Answer 12

the antidote for Heparin or LMWH OD

Question 13

Anti-ischemic agents = ?

Answer 13

1. beta blockers
2. nitrates

Question 14

What drug binds to ATIII to inactivate Xa?

Answer 14

LMWH

Question 15

What is the difference btw unstable angina and NSTEMI?

Answer 15

the presence of serum biomarkers = NSTEMI

Question 16

When would you decide to give a Ca++ blocker if the goal was to decrease myocardial O2 demand?

Answer 16

the pt cannot tolerate Beta-blockers

Question 17

Verapamil and diltiazem work by _____.

Answer 17

blocking the L-type Ca++ channel (phase 0 in nodal cells, phase 2 in cardiomyocyte)

Question 18

What are the 3 categories of antiplatelet agents? Examples?

Answer 18

1. COX1 inhibitors (low dose aspirin) 2. ADP/P2Y12 inhibitors (clopidogrel/Plavix) 3. GIIb/IIIa inhibitors (eptifibatide, tirofiban, abciximab) *** IV only

Question 19

What is an example of a direct thrombin (IIa) inhibitor?

Answer 19

dabigatran

Question 20

Beta-blockers are not direct _____.

Answer 20

vasodilators

Question 21

How does tPA work?

Answer 21

it activates plasminogen to plasmin, and plasmin lyses the clot

Question 22

What are the contraindications for beta-blockers?

Answer 22

1. excess bradycardia 2. severe heart block 3. Prinzmetal’s angina 4. asthma 5. concurrent Ca++ blockers

Question 23

How do statins work?

Answer 23

decrease LDL = prevent infiltration that leads to atherosclerosis

Question 24

How does LMWH work?

Answer 24

binds to ATIII to inactivate Xa

Question 25

What is the antidote for Heparin or LMWH OD?

Answer 25

protamine