10 - Basic Biopharmeceutics

Question 1

the bioavailability a drug product compared to the same drug in rapidly administered IV solution

Answer 1

absolute bioavailability

Question 2

the blood filtering process of the nephron

Answer 2

glomerular filtration

Question 3

drugs that activate receptors to accelerate or slow normal cellular function

Answer 3

agonists

Question 4

the time a drug will stay in the stomach before it is emptied into the the small intestine

Answer 4

gastric emptying time

Question 5

drugs that bind with receptors but do not activate them

Answer 5

antagonists

Question 6

the amount of an administered dose that reaches the general circulation and the rate at which this occurs

Answer 6

bioavailability

Question 7

the substantial degradation of an orally administered drug caused by enzyme metabolism in the liver before the drug reaches the systemic circulation

Answer 7

first-pass metabolism

Question 8

when different molecules associate or attach to each other

Answer 8

complexation

Question 9

the rime the drug concentration is above the MEC

Answer 9

duration of action

Question 10

the transfer of drugs and their metabolites from the liver to the bile and the gall bladder, then into the intestine, and then back into circulation

Answer 10

enterohepatic cycling

Question 11

a complex protein that catalyzes chemical reactions

Answer 11

enzyme

Question 12

the blood concentration needed for a drug to produce a response

Answer 12

minimum effective concentration (MEC)

Question 13

the blood concentration needed for a drug to produce a response

Answer 13

minimum effective concentration (MEC)

Question 14

a drug’s blood concentration range between it’s MEC and MTC

Answer 14

therapeutic window

Question 15

a drug’s blood concentration range between it’s MEC and MTC

Answer 15

therapeutic window

Question 16

drug products that contain the same active ingredient but no necessarily in the same salt form, amount, or dosage form

Answer 16

pharmaceutical alternative

Question 17

the bioavailability of a drug product compared to the same drug in any other dosage form than a rapidly administered IV solution

Answer 17

relative bioavailability

Question 18

the bioavailability of a drug product compared to the same drug in any other dosage form than a rapidly administered IV solution

Answer 18

relative bioavailability

Question 19

the substance resulting from the body’s transformation of an administered drug

Answer 19

metabolites

Question 20

the time MEC is reached and the response occurs

Answer 20

onset of action

Question 21

the attachment of a drug molecule to a protein, effectively making the drug inactive

Answer 21

protein binding

Question 22

the minimum amount of a drug’s blood concentration to have potentially harmful affects to the patient

Answer 22

minimum toxic concentration (MTC)

Question 23

the minimum amount of a drug’s blood concentration to have potentially harmful affects to the patient

Answer 23

minimum toxic concentration (MTC)

Question 24

the amount of times a drugs half-life must have elapsed for the elimination of a drug to be essentially complete

Answer 24

five times