11 - Factors Affecting Drug Activity

Question 1

this occurs when two drugs with similar pharmacological actions are taken (alcohol + sedative = increased drowsiness)

Answer 1

additive effect

Question 2

an abnormal sensitivity generally resulting in an allergic reaction

Answer 2

hypersensitivity

Question 3

a potentially fatal hypersensitivity reaction that produces severe respiratory distress and cardiovascular collapse

Answer 3

anaphylactic shock

Question 4

the ability of a substance to harm the kidneys

Answer 4

nephrotoxicity

Question 5

when one drug with no inherent activity of its own increases the activity of another drug, producing an effect

Answer 5

potentiation

Question 6

when one drug is moved from protein binding sites by a second drug, resulting in increased effects of the displaced drug

Answer 6

displacement

Question 7

when two different molecules associate or attach o each other

Answer 7

complexation

Question 8

a chronic and potentially fatal liver disease causing loss of function and resistance to blood flow through the liver

Answer 8

cirrhosis

Question 9

a chronic and potentially fatal liver disease causing loss of function and resistance to blood flow through the liver

Answer 9

cirrhosis

Question 10

when two drugs with with similar pharmaceutical actions produce an effect equal to the sim of their individual effects

Answer 10

synergism

Question 11

when two drugs with with similar pharmaceutical actions produce an effect equal to the sim of their individual effects

Answer 11

synergism

Question 12

this endogenous compound is used to monitor renal function

Answer 12

creatinine

Question 13

what hepatic function decreases by a hepatic disease

Answer 13

first-pass metabolism

Question 14

when the body creates this, hypersensitivity can happen

Answer 14

antibodies