Heme Cases Flashcards
1
Q
Most common cause of inherited hypercoagulability in whites?
A
Factor V Leiden
2
Q
Factor V Leiden MOA?
A
MOA: mutant factor V that is not destroyed by activated protein C
3
Q
Protein C or S deficiency?
A
MOA: ability to inactivate factors Va and VIIIa
4
Q
Skin and subcutaneous tissue necrosis after warfarin administration. What is the problem?
A
Think Protein C deficiency. “Protein C Cancels Coagulation.”
5
Q
Antithrombin deficiency. When is it a problem?
A
Inherited deficiency of antithrombin,
following Heparin administration b/c it diminishes the increase in PTT following heparin administration
6
Q
Prothrombin gene mutation MOA?
A
MOA: Mutation in 3′ untranslated region=>production of prothrombin=>plasma levels and venous clots
