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Uworld > Uworld Exam 14 > Flashcards

Uworld Exam 14 Flashcards

1
Q

Gag protein on HIV is? What does it encode for?

A

Gp 24

Capsule

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2
Q

Env protein on HIV is?

A

Gp 120, Gp41

Envelope=>to absorb the virion

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3
Q

Pol Protein on HIV is?

A

Reverse Transcriptase

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4
Q

CEA is for?

A

Tumor Recurrance

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5
Q

Suppressed with Dexamesthone?

A

Pituitary Adenoma

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6
Q

Not Suppressed with Dexamesthone?

A

Ecotopic ACTH production

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7
Q

Suppressed ACTH Levels?

A

Adrenal Adenoma/Exogenous Glucocorticoids

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8
Q

With Inhaled Corticoidsteroids, watchout for?

A

Oral Candidasis

Oral Rinse

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9
Q

Most Preventable cause of death?

A

Smoking

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10
Q

Ways to prevent mortality? What is #1 and #2

A 
#1=stop smoking
#2=aspirin therapy
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11
Q

Infant with poor feeding, increased head circumference and enlarged ventricles on CT?

A

Hydrocephalus

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12
Q

Long term complication of Hydrocephalus?

A

Hypertonicity and hyperreflexia due to Upper Motor Neuron Lesion

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13
Q

consists of two immunoglobulin monomers, J chain and secretory component. What is the immunoglobulin?

A

IgA

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14
Q

Ureteral Constriction decreases?

A

GFR and FF

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15
Q

How do you check for Menopause?

A

FSH and estradiol levels NOT LH

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16
Q

Actin attaches to?

A

An Interesting Zoo
Must Have Mammals

Actin I-Band to the Z line
Myosin H-band to the M-line

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17
Q

Sun Exposure leads to? How do you fix it? When does this occur?

A

DNA damage via pyrimidine dimers
Endonuclease nicking of the damaged DNA strand
G-1 phase

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18
Q

Ataxia-Telangiectasia MOA? You bring it together via?

A

MOA: 2 ds DNA breakage
Repair: Non-homologous end joining

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19
Q

Base Excision Repair MOA?

A

MOA: Base specific glycoylase removes altered base and creates AP site
Occurs throughout the cycle

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20
Q

Mismatch Repair occurs in what disease? When does this occur?

A

HNPCC

G-2 phase

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21
Q

PAO2 equation?

A

150-PaCO2/0.8

22
Q

Enoxaparin MOA

A

MOA: Binds to antithrombin to inhibit to factor Xa

23
Q

Fondaparinux MOA

A

MOA: Xa Inhibitor

24
Q

Unfractionated Heparin MOA

A

MOA: Binds to antithrombin to inhibit Factor Xa and Thrombin

25
Q

Zona fasciulata secretes?

A

cortisol

26
Q

Zona Reticulata secretes?

A

Androgen

27
Q

3 SD equals?

A

99.7%

28
Q

CN 9 innervates

A

Somatic: Stylopharygneus
Parasymp: Otic Ganglion=>parotid gland secretion
Sensation: tympanic membrane, eustachian tube, tonsillar region, upper pharynx (gag reflex afferent)
Others: carotid sinus and body

29
Q

DOC for malaria? If resistant, next line of choice?

A

DOC: chloroquine

Next in line: Mefloquine

30
Q

Difficulty walking with a history of diarrhea?

A

Guian Barre Syndrome with Camplyobacter (MC)

31
Q

After infusion of nitroprusside, patient feels lethargic and confused, lactic acidosis and bright red venous blood, what happened?

A

CN toxicity

32
Q

How do you treat CN Toxicity?

A

Sodium Nitrite=>makes it into methemoglobinemia

Sodium Thiosulfate=>Sulfur donating to change cyanate to thiocyanate

Hydroxycobalamin=>forms cyanocobalamin to be excreted

33
Q

Increased erythrocyte mass, facial pleothra, splenomegaly?

A

Polycythemia Vera

34
Q

Polycythemia vera has a mutated what pathway?

A

JAK2

35
Q

JAK2 is what kind of receptor

A

Cytoplasmic tyrosine kinase

36
Q

1st line for antiemetic therapy?

A

5-HT3 antagonist=>ondanstreon

37
Q

Vancomycin MOA AE?

A

MOA: Blocks glycopeptide polymerization by binding tightly to D-ALA, D-ALA
AE: Redman syndrome, Nephrotoxicity

38
Q

Daptomycin MOA AE?

A

MOA: depolarization of cellular membrane
AE: muscle pain, inactivated by pulmonary surfactant

39
Q

Linezolid MOA AE?

A

MOA: Inhibits bacterial protein syntehsis by binding to the 50s subunit
AE: Thrombocytopenia, Optic Neuritis, Serotonin Syndrome

40
Q

MCC of aseptic meningitis

A

Enterovirus

41
Q

Amyloid associated with Alzheimer’s is?

A

AB amyloid

42
Q

AB amyloid is made by what gene?

A

APP

43
Q

AB amyloid can lead to?

A

Amyloid angiopathy

44
Q

Isonazid Resistance?

A

Non expression of catalase peroxidase

45
Q

In primary renal insuffiency what will the lab values be for Na, K, Cl and Bicarb

A

Na=down
K=up
Cl=up
Bicarb=down

46
Q

EHEC produces a toxin that is most similar to?

A

Shigella

47
Q

Excessive worrying for over?

A

6 months

48
Q

MEN2A

A

Medullary Thyroid Cancer, Pheochromoctyoma and parathyroid

49
Q

What gene is affected in MEN 2A and 2B?

A

RET

50
Q

Medullary Thyroid Cancer Histology?

A

polygonal cells with extracellular amyloid deposits

Uworld (27 decks)

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