Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step 1 Exam > Reproductive Drugs > Flashcards

Reproductive Drugs Flashcards

1
Q

Leuprolide mechanism

A

-GnRH analog with agonist properties when used in a pulsatile fashion; antagonist properties when used continuously (downregulates GnRH receptor in the pituitary leading to decreased FSH/LH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Clinical use of Leuprolide

A

infertility prostate cancer uterine fibroids precocious puberty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Clinical use of estrogens (ethinyl estradiol, DES, mestranol)

A

-hypogonadism or ovarian failure -mesntrual abnormalities -HRT in postmenopausal women -used in men with androgen dependent prostate cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Toxicity of estrogens

A

-increased risk of endometrial cancer -bleeding -clear cell adenocarcionma of vagina (DES) -increased risk of thrombi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Estrogens are contraindicated in…

A

ER + breast cancer and those with a hx of DVTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Selective Estrogen Receptor Modulators (SERMs)

A

-Clomiphene -Tamoxifen -Raloxifene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Clomiphene is an…

A

antagonist at estrogen receptors in the hypothalamus that prevents normal feedback inhibition leading to increaed release of LH and FSH from the pituitary which stimulates ovulation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CLompihene is used to treat…

A

infertility due to anovulation (PCOS).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Clomiphene may cause…

A

hot flashes, ovarian enlargement, multiple simultaneous pregnancies and visual disturbances.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Tamoxifen is an…

A

antagonist on breat tissue and agonist in bone and the uterus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Tamoxifen is associated with…

A

endometrial cancer and thromboembolic events.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tamoxifen is primarily used to treat and prevent recurrence of…

A

ER + breast cancer.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Raloxifene is an…

A

agonist on bone and antagonist at the uterus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Raloxifene increases risk of…

A

thromboemblic events.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Raloxifene is used to treat…

A

osteoporosis bc it decreases resorption of bone.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

HRT is used for…

A

relief of menopausal symptoms and osteoporosis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Unopposed estrogen replacement therapy increases risk of…

A

endometrial cancer so progesterone is added.

18
Q

Anastrozole/Exemestane are…

A

aromatase inhibitors used in postmenopausal women with breast cancer

19
Q

Progestins MOA

A

bind progesterone receptors to decrease growth and increase vascularization of the endometrium

20
Q

Progestins Use

A

used in oral contraceptives and in treatment of endometrial cancer and abnormal uterine bleeding

21
Q

Mifepristone MOA

A

competitive inhibitor of progestins

22
Q

Clinical use of mifepristone

A

termination of pregnancy (administered with misoprostol (PGE1))

23
Q

In OCPs, estrogen and progestins inhibit…

A

LH/FSH and thus prevent the estrogen surge. No estrogen surge means no LH sruge means no ovulation.

24
Q

In OCPs, progestins cause…

A

thickening of the cervical mucus (limiting access to sperm) and they inhibit endometrial proliferation making it less suitable for implantation.

25
Q

Contraindications for OCPs

A

smokers > 35 hx of thromboembolism, stroke or estrogen-dependent tumors

26
Q

Terbutaline is a…

A

beta2-agonist that relaxes the uterus; usted to decrease contraction frequency in women during labor.

27
Q

Danazol MOA

A

synthetic androgen that acts as a partial agonist

28
Q

Use of Danazol

A

endometriosis and angioedema

29
Q

Toxicity of Danazol

A

-weight gain -edema -acne -hirsutism -masculinization -decreased HDL -hepatotoxicity

30
Q

MOA of Testosterone and Methyltestosterone

A

agonist at androgen receptors

31
Q

Use of Testosterone and Mehtyltestosterone

A

-hypogonadism -promotes development of secondary sex characteristics -stimulation of anabolism to promote recovery after burn or injury

32
Q

Toxicity of testosterone

A

-masculinization -decrease intratesticular testosterone (gonadal atrophy due to decreased LH) -premature closure of epiphyseal plates -increased LDL, decreased HDL

33
Q

Finasteride is a…

A

5alpha-reductase inhibitor that decreases the conversion of testosterone to DHT

34
Q

Finasteride uses

A

-BPH -male pattern baldness

35
Q

Flutamide is a…

A

nonsteroidal competitive inhibitor of androgens at teh testoterone receptor.

36
Q

Flutamide is used in…

A

prostate carcinoma.

37
Q

Ketoconazole inhibits…

A

steroid synthesis (inhibits 17,20-desmolase).

38
Q

Spironolactone inhibits…

A

steroid binding, 17alpha-hydroxylase and 17,20-desmolase.

39
Q

Ketoconazole and spironolactone are used in the treatment of…

A

PCOS to prevent hirsutism. Both have side effects of gynecomastia and amenorrhea.

40
Q

Tamsulosin is an…

A

alpha1-antagonist used to treat BPH by inhibiting smooth muscle contraction. Selective for alpha1A,D receptor found on prostate.

41
Q

Sildenafil and Vardenafil MOA

A

inhibit phosphodiesterase-5 causing increased cGMP, smooth muscle relaxation, increased blood flow and penile erection

42
Q

Toxicity of Sildenafil and Vardenafil

A

-dyspepsia -impaired blue-green color vision -risk of life-threatening hypotension in pts taking nitrates (since they block teh breakdown of NO)

Step 1 Exam (32 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions