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IHO > Week 4 Friday > Flashcards

Week 4 Friday Flashcards

1
Q

Mantle cell lymphoma

A

t(11,14) translocation (heavy chain)

Low grade NHL

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2
Q

Follicular lymphoma

A 
t(14,18)
back to back follicles
Grade 1-3 (3 bad)
Low grade NHL
Can spread to other tissues as white dots (which are follicules)
hang out next to trabecular
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3
Q

Follicular lymphoma blood smear:

A

Little cells with slit
“Butt cells”
Low grade NHL

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4
Q

Marginal zone lymphoma

A

low grade NHL
Malt lymphoma
Associated with w helicobacter pylori

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5
Q

mycosis fungoides / sezary syndrome

A 
low grade NHL
skin lesions
blood involvement
*cerebriform lymphocytes (look like brains)
*t-cell immunophenotype
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6
Q

sezary syndrome

A

end resuld of mycosis fungoides low grade NHL

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7
Q

pautrier microabscess

A

found in mycosis fungoides. in the skin.

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8
Q

Benign lymph node enlargement

A

most common
caused by infection
soft when palpating
can be painful

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9
Q

Malignant lymphadenopathy

A

most common cause is metastatic carcinoma
Hard when palpating
Painless

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10
Q

diffuse large cell lymphoma

A

large B cells
extranodal involvement, large cells that grows fast
bad prognosis
High grade NHL

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11
Q

lymphoblastic lymphoma

A 
type types: t and b
lymphoblasts diffuse pattern
Same as ALL
often seen in teenage MALE with mediastinal mass
High grade NHL
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12
Q

Burkitt lymphoma

A

Children, extranodal mass
STARRY SKY PATTERN
african type (jaw) and non african type (abdomen)
t(8;14) (same as burkitt leukemia)

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13
Q

Starry sky pattern

A

Found in burkitt lymphoma

white dots are tingle body macrophages

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14
Q

Adult t-cell leukemia/lymphoma

A

japan/caribbean basin
HTLV-1 (virus)
skin lesions, hypercalcemia
very aggressive

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15
Q

tingle body macrophage

A

non malignant macrophage just eating up all debris from high turnover. See them in germinal centers or any tumor that grows fast

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16
Q

T cell lymphomas?

A

Adults t-cell leukemia and mycosis fungoides

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17
Q

Burkitt leukemia microscope:

A

starry sky patterns. Cells have clear dots (vacoules)

18
Q

Hodgkins vs NHL

A

Hodgkins is contigous spread
NHL is very sporadic and most are B cells
Hodgkins nodules are larger on liver and spleen

19
Q

Hodgkins lymphoma must know:

A

younger patients, good prognosis
Even spread
Five subtypes
Reed-sternberg cell

20
Q

Reed sternberg cell

A

Very large cell with 2/nuclei that are as big as lymphocytes “owl eyes”
Hodgkins lymphoma!
Malignant part of the disease. Release cytokines to recruit cells, but recruited cells are not malignant

21
Q

Hodgkins lymphoma subtypes

A

Nodular lymphocyte predominance

Classical:
nodular sclerosis
lymphocyte rich
mixed cellularity
lymphocyte depletion
22
Q

Nodular lp hodgkin lymphoma

A

good prognosis
usually asymptomitc and young male with cervical lymphadenopathy

Bcell origin with POPCORN cells

23
Q

nodular sclerosis hodgkin lymphoma

*

A

good prognosis
most common of classicaly subtype
LACUNAR cell
Fibrotic bands that seperate nodules

24
Q

mixed cellularity hodgkin lymphoma

A

Bad prognosis

Classic reed-sternberg cells with mixed background of cells

25
Q

lymphocyte rich HL

A

uncommon

popcorn cells

26
Q

Treatment for HL

A

Surgery, chemo, radiation
Prognosis depends on STAGE
Danger: second malignancies

27
Q

Small lymphocytic lymphoma

A 
Low grade NHL
small mature lymphocytes
Same as CLL
Bcell lesions w/CD5
Long course
Richter transformation
28
Q

Richter Transformation

A

Sound in SLL/CLL

29
Q

Low grade NHL

A

older patients
incurable
small mature cells
non-destructive

30
Q

High grade NHL

A

children
aggressive
big ugle cells
destructive

31
Q

Symptoms of NHL

A

Painless firm lymphadenopathy
Extranodal manifestations

B symptoms make it worse: weight loss, night sweats, fever

32
Q

Follicular hyperplasia

A

large, irregular follices

mixture of cells in germ centers

tingible body macrophages

B-cell response to some immune stimulus

33
Q

Interfollicular hyperplasia

A

Expanded between follicles

mixture of cells

Partial effacement

T-cell response to some immune stimullus!!

34
Q

Chronic lymphoproliferative disorders musk know:

A

Many disorders: CLL most important
ONLY in adults

Long course

35
Q

CLL must know

A

small, mature lympocytes

B-cell, with CD5+ (normally on only tcell)
TdT Negative
Long course
HYPOGAMMAGLOBULINEMIA

36
Q

Pathophysiology of CLL

A

bcl-2 gene rearrangement

bcl-2 prevents apoptosis

Gets stuck next to gene that turns it on at all times

Treat conservative. death usually from infection

37
Q

Hairy cell leukemia

CLD

A

Hairy cells
Splenomegaly WITHOUT LYMPHADENOPATHY

pancytopenia

TRAP+ STAIN

38
Q

Hairy cell leukemia bone marrow aspiration

A

HARD to pull out bone marrow. Bone marrow stuck together with fibrosis

39
Q

Hairy cell leukemia chem and immunophenotype. Labs?

A

TRAP +

Positive for B-cell antigen, CD25 AND CD11C

Negative for CD5

Always MONOCYTOPENIA

40
Q

Prolymphocytic leukemia

CDL

A

splenomegaly WITHOUT LYMPADENOPATHY

rare and aggressive

Nucleoli show through on blood smear

41
Q

Large granulated lymphocyte leukemia must know:

A

Large granulated lymphocytes

T CELL

Neutropenia with long survival

IHO (9 decks)

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