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Pharmacology and Drugs / Poisons 9.14 > GORD Drugs 05.15 > Flashcards

GORD Drugs 05.15 Flashcards

1
Q

Match the treatment to the mechanism:

  1. Neutralise acid
  2. Reduce irritancy of acid
  3. Mucosal defence
  4. Gastric stimulants
  5. Reduce acid production

a. PPIs / H receptor antagonists
b. Antacid
c. Metclopramide / domperidone
d. Sucralfate, misoprostol
e. Alginates (sodium bicarb, alumin and ca+ salts)

A
  1. Neutralise acid - antacids
  2. Reduce irritancy of acid - Alginates
  3. Mucosal defence - Sucralfate, misoprostol
  4. Gastric stimulants - Metclopramide / domperidone
  5. Reduce acid production - PPIs / H receptor antagonists.
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2
Q

S/E of aluminium and calcium based alginates

A

Constipation

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3
Q

How do alginates work simply

A

Increase viscosity of stomach contents

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4
Q

This med stimulates prostoglandin production as well as bicabonate

A

Sucralfate

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5
Q

SE of Sucralfate

A

Constipation

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6
Q

Interactions of sucralfate (3)

A

Digoxin, antibiotics, phenytoin

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7
Q

This med is a prostaglandin analogue - acts at prostaglandin receptors

A

Misoprostol

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8
Q

Misoprostol SE

A

Diarrhoea

Abd pain

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9
Q

Misoprostol contraindicated in which people

A

Pregn and child bearing age women

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10
Q

These 2 drugs are gastric stimulants - incr peristalsis in duodenum & jejenum by stimulating muscarinic receptors

A

Domperidone / metoclopramide

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11
Q

Ranitidine, cimetidine, nizatidine, famotidine, all what type of drug

A

H2 receptor antagonists - bind to H2 receptor and suppress acid production

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12
Q

SE of H2 receptor antagonists

A

Diarrhoea, headache constipation, confusion, hallucinations

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13
Q

Cimetidine is a CYP450 inhibitor or inducer?

A

Inhibitor

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14
Q

Omeprazole, lansoprazole etc are what type of drug

A

PPI - Proton Pump Inhibitor

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15
Q

Omeprazole interacts with what anti platelet drug

A

Clopidogrel

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16
Q

Why do NSAIDs cause stomach irritation

A

Prevent protective prostaglandin production from COX1

also stop inflammatory prostaglandins from COX2 - good for pain

17
Q

Combining PPI with antibiotics is recommended for eradication of what bacteria

A

Helicobacter pylori (gastric and duodenal ulcers)

Pharmacology and Drugs / Poisons 9.14 (7 decks)

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