Cancer and Anti-emetics

Question 1

Which class are the follow drugs under:
methotrexate [Trexall®]
trimethoprim [Primsol®]
pyrimethamine [Daraprim®]
pemetrexed [Alimta®]

Answer 1

Anti-metabolites

Question 2

Methotrexate is indicated for what?

Answer 2

RA, psoriasis and choriocarinoma

Question 3

What is the black box warning for methotrexate and another severe adverse effect?

Answer 3

neurotoxicity

black box: deaths reported; monitor bone marrow, liver, lung & kidneys.

Question 4

Which drug has a black box warning of opportunistic infections?

Answer 4

methotrexate

Question 5

When methotrexate is mixed with NSAIDs it can result in fatal _________

Answer 5

myelosuppression

Question 6

NSAIDs, sulfonamides, ciprofloxacin, & penicillins (NSCP) have a reaction with methotrexate where _______.

Answer 6

You get reduced elimination and additive effects

Question 7

Apart from NSAIDs, methotrexate also has an additive myelosuppression effect with which other drug?

Answer 7

ganciclovir

Question 8

What does DHFR stand for and what product does it produce?

Answer 8

dihydrofolate reductase; producing FH4;

Question 9

What does methotrexate inhibit?

Answer 9

DHFR