Mixed High Yield Flashcards
What is atropine?!?
a reversible competitive muscarinic receptor antagonist
Volume overload of the left ventricle, as in aortic regurgitation, causes _______ hypertrophy.
eccentric (“in-series” sacromere synth)
Pressure overload of the left ventricle, as in aortic stenosis or systemic htn, causes _______ hypertrophy.
concentric
What is the first area of the brain damaged in global cerebral ischemia?
hippocampus
What cells secrete inhibin in males? Where are they located?
Sertoli cells; line seminiferous tubules
What cells secrete inhibin in the female? What stimulates its secretion?
Granulosa cells; FSH
Homocysteine is produced following what biochemical event?
Methyl donation by SAM
What 2 enzymes may be deficient in homocysteinuria?
Cystathionine synthase;
Homocysteine methyltransferase
(aka methionine synthase)
What is the result of high plasma homocysteine levels at the molecular level?
Formation of disulfide bonds w/ Cys residues on proteins
What are the clinical features of homocysteinuria? (6 things)
DVT, Stroke, atherosclerosis;
Marfan-like habitus; mental retardation; joint contractures
What cofactor(s) is/are required for homocysteine methyltransferase?
B12 and N-methyl-THF
What cofactor(s) is/are required for cystathionine synthase?
B6
What is the first symptom of ischemic damage from a global cerebral infarct?
Short-term memory loss.
What is a common cause of global cerebral ischemia?
cardiac insufficiency
What do inhibins and activins do?
Regulate FSH secretion.
