Vaccines (lect 4) Flashcards
How is the source of infection genotyped?
Multilocus sequence typing.
Attribution experiment.
What is MLST?
Reveals interspecies hybrids
What is bottom-up and top-down?
Bottom-up:
Start with DNA and test effects on the phenotype
Top-down:
Start with phenotype and associates it with particular genomic elements
What is Genome Wide association study? (GWAS)
Looking at similarities of the biochemistry of different strains
How many people die of infectious and parasitic diseases every year?
10million
What is horizontal gene transfer?
The transfer of genes between DIFFERENT genomes. Can occur between prokaryote and eukaryote species.
What are the organs associated for the following pathogens?
Neonatal meningitis E.coli (NMEC)
Brain and bloodstream
What are the organs associated for the following pathogens?
Uropathogenic E.coli (UPEC)
Bloodstream, Kidney, Bladder
What are the organs associated for the following pathogens?
Enterohaemorrhagic E.coli (EHEC)
Large bowel
What are the organs associated for the following pathogens?
Enteroinvasive E.coli (EIEC)
Large bowel
What are the organs associated for the following pathogens?
Enteroaggregative E.coli (EAEC)
Large bowel, Small bowel
What are the organs associated for the following pathogens?
Enteropathogenic E.coli
Small bowel
What are the organs associated for the following pathogens?
Enterotoxigenic E.coli
Small bowel
What are the organs associated for the following pathogens?
Diffusely-adherent E.coli
Bladder
What is the main contributor to the virulence of E.coli?
Mobile genetic elements and horizontal gene transfer
