ABX (A) from apea FNP (sasmall) Flashcards
Gram Negative Bugs
Almost everything else
Gram Positive Bugs
- Staph
- Strep
- Enterococcus
Staphylococcus
Gram +
- Staphylococcus aureus (skin)
- MRSA (skin)
- Staph saprophyticus (UTI, vagina)
- Staph epidermis (skin)
Streptococcus
Gram +
- Strep pyogenes (throat)
- Strep pneumoniae (lungs)
- Strep viridans (dental abscess, endocarditis)
- Strep agalactiae (Group B strep)
Enterococcus
Gram +
- Enterococcus faecalis (urinary tract)
- Enterococcus faecium (urinary tract)
Gram Negative Bugs
- Neisseria gonorrhoeae
- Neisseria meningitides
- E. coli
- Shigella
- Campylobacter
- Salmonella
- Pasturella (cat bites)
- Mycoplasma
- H. flu
- M. catarrhalis
- Proteus
- Pseudomonas
- Legionella, etc……
Penicillins
Coverage: Gram + (NOT MRSA or MSSA)
- ampicillin
- amoxicillin
- penicillin G
- penicillin K
Extended Spectrum PCNs
Coverage: Gram +, Gram Neg., B-lactamase (NOT MRSA or MSSA)
-amoxicillin/clavulanic acid
Tetracyclines
Coverage: Gram neg, atypicals, MRSA
- doxycycline
- minocycline (preferred for tx of MSSA & CA-MRSA)
- vibramycin
Sulfonamides
Coverage: Gram neg, MRSA
-TMP/SMX
Cephalosporins: 1st generation
Coverage: Gram +
- cephalexin
- cefadroxil
Cephalosporins: 2nd generation
Coverage: Gram + and Gram neg
- cefuroxime
- cefaclor
- cefprozil
Cephalosporins: 3rd generation
Coverage: Gram neg. (weak Gram +)
- ceftibuten
- cefixime
Extended Spectrum 3rd Generation
Coverage: Gram +, Gram neg., B-lactamase
- ceftriaxone
- cefdinir
- cefpodoxime
- cefditoren
Macrolides
- erythromycin: atypical pathogens (NOT Staph, Strep, or Enterococcus)
- azithromycin and clarithromycin (NOT Strep)
Fluoroquinolones
- Cipro: Gram neg., atypical pathogens (for bugs below the belt)
- Respiratory Fluoroquinolones: Gram +, Gram neg., atypical pathogens, and DRSP: levofloxacin, moxifloxacin, gemifoloxacin, gatifloxacin
- Do NOT give to patients <18yo or if pregnant
SSRIs
-fewer side effects and less danger of overdose
-Tx: dysthmia, OCD, and anxiety disorders
E.g.: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, fluvoxamine
- Serotonin syndrome: potentially life threatening, hyperreflexia, clonus, rigidity in the lower extremities, tachycardia, hyperthermia, hypertension, vomiting, disorientation, agitated, delerium, or tremor.
- -can occur from an interaction between an SSRI and dextromethorphan, triptan, or other SSRIs
Dopa/Norepi RIs
-Few side effects: no weight gain, drowsiness, orthostatic hypotension, or sexual dysfunction
E.g.: bupropion
SNRIs
-similar side effects as SSRIs
E.g.: venlafaxine, duloxetine, desvenlafaxine
TCAs
- Side effects include: sedation, dry mouth, peripheral vasodilation
- NOT as safe in overdose or in pts w/ bradyarrhythmias
- Useful in patients with depression and chronic pain or migraine
- E.g.: amitriptyline, clomipramine, desipramine, doxepin, nortriptyline, protriptyline
Black cohosh
herb for hot flashes
St. John’s Wort
herb for depression
Milk thistle
herb for liver, GI
Red yeast
herb for high cholesterol
Serotonin syndrome
sleepy to coma, potentially life threatening, hyperreflexia, clonus, rigidity in the lower extremities, tachycardia, hyperthermia, hypertension, vomiting, disorientation, agitated, delerium, or tremor.
–can occur from an interaction between an SSRI and dextromethorphan, triptan, or other SSRIs
HTN meds
- Triamterene: K+ sparing
- ACE inhibitors: raises serum K+
- HCTZ: increases serum Ca2+ (Good for osteopenia, Bad for gout, DM, and hyperlipidemia)
- Do NOT use CCBs w/ thiazide diuretics
- CCBs do NOT effect the pulse
- In pregnancy: do NOT use ACEs or ARBs
GLP-agonists (incretin-mimetics)
-enhances insulin secretion
-weight loss, delays gastric emptying
-injected, expensive
E.g. Byetta, Victoza
Thiazolidinedione (TZDs)
- No hypoglycemia, improves insulin sensitivity
- Expensive, weight gain, edema, high dose associated with bone fractures
- E.g. **pioglitazone (Actos)—-Do NOT use in HF
Insulin
- reduces BG levels, weight gain
- hypoglycemia
- STOP sulfonylureas before when initiating meal time insulin
When to consider insulin?
- HgbA1C >10%
- fasting glucose >250
- after maxing out po therapy
- symptoms of hyperglycemia
- pregnant patients
Thyroid Values
- TSH: 0.5 - 4.5 (produced by anterior pituitary)
- Normal Serum Free T4: 0.8 - 1.8
- Replace adults with 1.6mcg/kg/day of levothyroxine
- Adults >50yo start at 50mcg daily of levothyroxine
- **Recheck TSH in 4-6wks
T-score
- Osteopenia between -1.0 and -2.5
- Osteoporosis < -2.5
Breast Cancer Screening Recommendations
- CBE q 1-3yrs from age 20-39
- Mammogram and CBE annually at age 40
- CBE q 1yr + mammogram q 2yrs at age 50+
Saw Palmetto
Herb for prostate health
BPH
-Prostate: firm, smooth, symmetrically enlarged prostate
Prostatitis
- Pain in the perineum, lower abdomen, testicles, or penis; pain with ejaculation; voiding difficulty
- Prostate: enlarged, boggy, and tender, fever, cloudy urine, frequency, urgency, pain with defecation, hematuria
- no significant elevation in PSA
- Cipro for 6 weeks, alpha blocker, NSAIDs, stool softeners, adequate fluids
Prostate Cancer
- Prostate: asymmetry, induration, nodularity, hard
- Normal PSA < 4.0
- PSA >10 Needs biopsy
Prostate Cancer Screening
- Start screening at age 50; High risk begin discussions at 40-45
- If PSA < 2.5; test q 2yrs
- If PSA > 2.5; annual testing
- If PSA > 4.0; refer for evaluation
Honey colored crusts
impetigo
Tx w/ topical antibiotics
Herald patch
pityriasis rosea
Christmas tree pattern rash
distribution of pityriasis rosea
Burrows
scabies
well circumscribed lesion found on the trunk
tinea corporis
sandpaper textured rash
strep (trunk)
pearly domed nodule
basal cell
bright, beefy, red rash
candida (diaper)
silvery scales
psoriasis
Bull’s eye lesion
Lyme disease
Nits
head lice
RBC casts indicate
glomerulonephritis, urinary tract injury
WBC casts indicate
inflammation (nephritis, post-Strep glomerulonephritis), infection, or pyelonephritis
Epithelial casts
acute tubular necrosis, hepatitis, anything that causes epithelial cell death
Chlamydia
- often asymptomatic, vaginal tenderness, cervical motion tenderness, dysuria, salpingitis,proctitis, epididymitis
- associated with PID, infertility, ectopic pregnancy
- Tx: doxycycline 100mg bid for 7 days or azithromycin 1G once
- refer sexual contacts in past 2months
- rescreen in 3mo after tx
Gonorrhea
- often asymptomatic, endocervical/urethral discharge (gr.), dysuria, Bartholin’s gland abscess, testicular pain
- Tx: ceftriaxone 250mg +azithromycin 1G, or doxycycline 100mg bid for 7 days
Trichomoniasis
- frothy, diffuse, and yellow-green discharge, cervical petechiae “strawberry cervix”
- Tx: metronidazole 2G 1x or tinidazole 2G 1x orally
- Treat sexual partners
Syphilis
- Tx: penicillin G 2.4 million units IM
- *If Pen allergic can use doxycycline, tetracycline, or erythromycin
- Primary stage: painless chancre
- Secondary stage: lymphadenopathy
- Latent: seropositive, but asymptomatic
- Tertiary: serious symptoms of cardiac insufficiency or an aortic aneurysm
Folic Acid in Pregnancy
0.4 - 0.8mg daily
Naegele’s Rule
-subtract 3 months from the LMP then add 7 days and 1 year
Uterine Size
- 12wks: palpable just above the symphysis pubis
- 16wks: palpable midway between symphysis pubis and umbilicus
- 20wks: at level of umbilicus
-McDonald’s rule. Between 16 and 34 weeks, the height of the fundus approximately equals the number of weeks gestation. Measurements are taken from the top of the symphysis pubis to the top of the fundus in a straight vertical line. The patient’s bladder should be empty for accurate measurement.
quickening
first perceived in a primipara around 17-20wks
Placenta previa
- Improper implantation of the placenta in the lower uterine segment
- Painless
Maternal Assessment of Fetal Activity
- Kick counts
- lie on Lt side after eating and count kicks for 30 minutes
- should move 3-5 times in an hour
Pyloric stenosis
- symptoms begin at 3-5 weeks of age
- olive like mass palpated after vomiting, hypertrophied pyloric ms
- ultrasound to dx
Intussusception
- sausage-like mass palpable in the RUQ
- child 3-11 mo cries and pulls legs up to chest (colick expected at 1-3mo)
- intermittent colicky abdominal pain, vomiting, bloody mucous stools, currant jelly stools
- dx with KUB or ultrasound
- surgery required
Undescended testes
-refer if not descended by 6mo
Pediatric UTI
-bowel or bladder dysfunction: withholding maneuvers, incontinence, constipation
-vesicoureteral reflux
-tx with 3rd generation cephalosporin: cefixime, cefdinir, ceftibuten for 3-5 days if afebrile and 10 days if febrile
-if febrile refer to urology
renal bladder ultrasound (RBUS) for all infants 2-24 months with first febrile UTI
Kawasaki disease
- acute generalized systemic vasculitis, leading cause of acquired heart disease in children, etiology unknown
- fever for 5 days + 4 of 5 criteria of coronary vessel involvement
1. bilateral conjunctival injection without exudate
2. polymorphous rash urticarial, or pruritic
3. inflammatory changes of lips and oral activity (strawberry tongue)
4. changes in extremities (edema, desquamation of hands and feet)
5. cervical lymphadenopathy (unilateral, anterior cervical) - refer for IV immune globulin and aspirin
- NO need to isolate
Roseola
Human Herpesvirus 6
Fifth disease (erythema infectiosum)
Parvovirus B19
- “slapped cheek” rash; lacey macular rash, pruritic, palms and soles may be affected
- spread via respiratory droplets
- fever, malaise, sore throat, lethargy,
- ok to return to school after 24hrs fever-free
- infection on pregnancy associated with 10% chance of fetal death
Rubella
Rubella virus
-Maculopapular rash, looks like measles, remarkable lymphadenopathy, macules on soft palate
Rubeola (measles)
Rubeola virus
- Maculopapular “brick red” rash; starts on head and neck, spreads to trunk and extremities
- 3 C’s: conjunctivitis, coryza, and cough
- develop Koplik’s spots: 1-3mm whitish-bluish, grey elevations on the buccal mucosa, hard, and soft palates
Varicella Zoster
Herpes virus
-vesicular lesions on erythematous base appearing in crops
Herpangina
Coxsackie A virus
Hand Foot and Mouth disease
Coxsackie virus A16
Milia
white papules on nose and cheeks
Mongolian spots
congenital with indefinite borders; buttocks and base of spine; predominately in African American and Asian infants
Nevus simplex
“stork bite”, pink red capillary on face or neck
Nevus flammeus
port wine stain anywhere on body
Fontanelles
- anterior closes at 9-18 months
- posterior closes 2 months (not always open at birth)
Hypertelorism
-eyes far apart; associated with many syndromes
Evoked otoacoustic emission testing
-method for universal screening of hearing in newborns
Symptoms of TIA usually last
< than 24 hrs
Joints involved in OA
fingers, knees, hips
Aphthous ulcer
“canker sore”, painful, usually heal in 5-14 days
Leukoplakia
white or grey patches on the inside of the mouth that occur d/t long-term irritation (no pain). May be a sign of oral cancer.
Diverticulitis
- tenderness usually on LLQ
- bloating, gas
- fever and chills
- nausea and vomiting
- low fiber diet (feces trapped in pouches leading to inflammation or infection)
GERD
- hoarseness, cough, chest pain, nocturnal symptoms, heartburn
- perform endoscopy if pt over 50 yo, have an inadequate response to PPI therapy, or have dysphagia or odynophagia (Barret’s esophagus?–precancerous
- pyrosis: heartburn
Brain natriuretic peptide (BNP)
substance secreted by the ventricles in response to changes in pressure that occur when heart failure develops and worsens.
Erysipelas
- Involves upper dermis, superior lymphatics
- raised above level of surrounding skin
- fever and chills with acute onset
- often affects ear, face, and lower extremities
- commonly caused by Strept
Tanner Stages Female
- Begin at age 8
1. Prepubertal: papilla elevated above chest wall
2. Breast budding (8-13yo)
3. breast and areola enlarge
4. secondary mound formed by areola and papilla
5. adult breast
*growth spurt stage II - III
Sprain Grades
I: minimally torn ligament, stable joint
II: more severely torn ligament, stable joint
III: completely torn ligament; severe pain; swelling, tenderness, no weight bearing–refer to Ortho
*Eversion sprain more serious—-refer
Gestational DM Screening
- all pregnant women at 24-28 weeks
- 2 step screen, OGTT
Allergic Rhinitis
-inflammation of the mucous membranes of the nasal tract with subsequent mucosal edema, clear discharge, sneezing, itching, and nasal stuffiness.
-intranasal glucocorticoids (single most effective treatment): budesonide, fluticasone, mometasone, ciclesonide
-non-sedating antihistamines: loratadine, fexofenadine, levocetirizine
*cetirizine is NOT non-sedating
Other agents: decongestants, leukotriene blockers, mast cell stabilizers
Osteoarthritis
- pain exacerbated by activity, relieved by rest
- AM stiffness that resolves within 30 mins
- tenderness to palpation, crepitus, Bouchard’s nodes
- osteophytes and joint space narrowing on x-ray
- Tx: Move!, weight loss, tylenol, NSAIDs, heat/cold application
Rheumatoid Arthritis
- autoimmune disease
- symmetric, peripheral polyarthritis
- commonly affects: MCP, PIP, and MTP joints
- AM stiffness lasts longer than 30 mins, improves as the day progresses
- rheumatoid nodules
- erosion of cartilage and bone on x-ray
- Tx: methotrexate, sulfasalazine, hydroxychloroquine, target cytokines, infliximab
- refer to rheumatology
RICE Therapy
R: rest
I: ice
C: compression
E: elevation
Analgesics: acetaminophen and NSAIDs
Tanner Stages Male
- Begin at age 8
1. 1cm testes, scrotum and penis as seen in early childhood
2. scrotum becomes reddened and textured (10-13.5)
3. Further testicular growth, slight enlargement of penis
4. penis increases in length and diameter, testes enlarge (4-5cm)
5. adult genitalia
*growth spurt stage III - IV
Tanner Stages Pubic Hair
- Begin at age 8
1. No pubic hair present
2. sparse, lightly pigmented
3. hair becomes more pigmented, coarse, curled, and more abundant
4. pubic hair abundant, but covers smaller area than in an adult
5. adult hair distribution
6. Hair grows up linea alba
2 Month Milestones
- focuses on face
- grasps rattle if placed in hand, (shakes it)
- smiles, coos
- able to lift head 45 degrees
4 Month Milestones
- able to hold head and control head when held upright
- reach for objects
- no head lag when pulled upright
- raises body on hands
- rolls prone to supine
- follows light 180 degrees
6 Month Milestones
- able to place object in opposite hand and in mouth
- sits with support
- unilateral reaching
- rolls supine to prone
- bears weight
- recognizes parent
- says “dada” or “baba”
- babbles
- smiles, squeals, laughs, imitates sound
9 Month Milestones
- pulls to stand
- bangs, shakes, drops, and throws objects
- able to feed self with finger foods
- responds to own name and knows a few words
- stranger anxiety
- crawls, creeps, and scoots
12 Month Milestones
- pulls to stand, may take a few steps
- uses pincer grasp and able to point
- says 2-4 words
- looks for dropped or hidden objects
- responds to own name and understands a few words
- feeds self and drinks from a cup
- waves and says “bye-bye”
- imitates vocalizations
15 Month Milestones
- walks well and is able to stoop
- can point to a body part
- says 3-6 words
- stacks 2 blocks
- follows simple commands
- points, grunts, pulls to show what they want
- listens to a story
18 Month Milestones
- able to walk backwards
- can throw a ball
- says 15-20 words
- imitates words, uses two word phrases
- points to multiple body parts
2 Year Milestones
- able to walk up and down stairs one step at a time
- can kick a ball
- says at least 20 words
- imitates adults
- follows 2 step commands
- stacks five blocks
3 Year Milestones
-able to jump
-can stand on 1 foot
-able to ride a tricycle
-says name, age, and gender
-knows gender of others
-able to copy a cross, circle
able to recognize colors
4 Year Milestones
- able to sing a song
- can hop on one foot
- able to throw a ball overhand
- able to draw a person with three parts
- able to cut and paste
- able to build a tower with 10 blocks
- counts to five
- able to copy a square
- able to dress self with supervision
5 Year Milestones
- able to draw a person with body, head, arms, legs
- able to recognize most letters and can print some
- plays make believe
- learns address and phone number
- can define at least one word
Immunization: Hep A
- all children at 12mo
- 2nd dose 6mo later
Immunization: Hep B
#1 birth #2 age 1-2 months #3 age 6 mo (at least 2mo after 2nd dose)
Immunization: DTaP
#1 at 2mo #2 at 4mo #3 at 6mo #4 12-18mo #5 4-6 years
Tdap booster
- adolescents 11-12 yo
- Td q 10yrs
Immunization: Hib
#1 age 2mo #2 age 4mo #3 age 6mo #4 age 12-15mo
- Not needed after 5 years of age
- If there is any household contact under 4 years-of-age who has not been immunized, rifampin prophylaxis should be given to all household contacts, including the adults.
Immunization: IPV
#1 age 2mo #2 age 4mo #3 age 6-18mo #4 age 4-6 years
Live Vaccines
- MMR, Varicella, Rotavirus, Flu mist, Zostavax
- rash after live or attenuated immunizations represents a reaction to viral replication, not the vaccine
- *No live vaccines prior to 1 year of age (except rotavirus)
Immunization: MMR
#1 12-15mo #2 4-6yrs
- Do NOT give in pregnancy, and avoid pregnancy for 28 days post immunization
- Ok if breastfeeding
Immunization: Varicella
#1 12-18mo -booster at 4-6 years
Immunization: Influenza
- annually for >6mo
- children < 8yo receiving IM for the first time, need 2 doses separated by 1 month
Immunization: MCV4
- at age 11-12yo
- Booster at age 16
Immunization: HPV
-minimum age 9yo #1 11-12yo #2 2mo later #3 6months after first dose
-Administer at 0, 2, and 6months
Immunization: Zostavax
- 1 dose at age 60
Cellulitis
- Involves deeper dermis, subcutaneous fat
- has poor demarcation
- often no systemic symptoms; localized symptoms noted with onset over a few days
- often seen periorbital, lower extremities
- Streptococcus pyogenes most common cause
- Other causes: Staph aureus
Medicare Part A
-covers inpatient hospital care, skilled nursing facility, hospice, and home health care
Medicare Part B
-covers doctor and other health care provider’s services, outpatient care, durable medical equipment, home health care. and some preventative services