Flashcards in 4 Deck (7):
Categories of stem cells
Fertilized zygote--totipotent1. Embryonic stem cell--pleuripotent2. Fetal/perinatal stem cell3. Adult stem cell--multipotent4. Induced stem cell--pleuripotent
Induced pleuripotent stem cell
iPS cellProduced by reprogramming of adult somatic cellsRequires transdifferentiation and redifferentiation of fully differentiated cells into pleuripotent cells
Types of adult stem cells
1. mesenchymal/stromal2. hematopoetic3. neural
what is the ultimate validation of pluripotency seen in embryonic and induced stem cells
where do adult hematopoetic stem cells come from?
Bone marrowautogenous/allogeneictarget cells for bone marrow transplantation
where can mesenchymal/stromal stem cells come from?
Bone marrow, adipose tissue, umbilical cord, muscle, and other tissue (cartilage, tendon, tonsil, dental pulp)function to secrete trophic factorsimmunotolerant