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Tri 6 - Tumors > 4. Osteosarcoma > Flashcards

4. Osteosarcoma Flashcards

(55 cards)

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1
Q

Undifferentiated connective tissue and forms of neoplastic osteoid

A

Central Osteosarcoma

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2
Q

other types of osteosarcomas

A
  • Multicentric
  • Parosteal
  • Secondary
  • Extraosseous
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3
Q

Second m/c primary malignant bone tumor

A

Central Osteosarcoma

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4
Q

20% of all primary bone tumors, mostly in 10-25 year olds.

A

Central Osteosarcoma

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5
Q

Painful swelling at site of lesion (85%), with weight loss, fever, and cachexia

A

Central Osteosarcoma

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6
Q

May take ______ or longer to DX the central osteosarcoma tumor

A

6 months

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7
Q

Central osteosarcomas likes ____ bones,

A

long

primarily knee and shoulder

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8
Q

• 58% of Central osteosarcomas tumors occur around the ____.

A

knee

Typically located in metaphysis

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9
Q

m/c affected structure in spine from osteosarcoma

A

Vertebral body

comp. Fx

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10
Q

Secondary Osteosarcoma arise in Paget’s bone at __ %

A

44

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11
Q

If patient has Paget’s disease measure -__________ as a baseline study

A

alkaline

phosphatase

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12
Q

Will Alkaline Phosphatase
levels return to normal with removal of
tumor?

A

yes

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13
Q

__ % of Central osteosarcomas are neoplastic sclerotic bone, __ % are Purely lytic
and __ % are Mixed.

A

50, 25, 25

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14
Q

Pulmonary metastasis in osteosarcoma via hematogenous

route

A

Cannonball Metastases

ossfified

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15
Q

Cannonball metastases represents

A

sarcomatous pulmonary bone growths

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16
Q

Common subpleural nodules that have undergone

excavation –> rupture

A

Spontaneous Pneumothorax

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17
Q

Skeletal Metastasis may occur, called

A

Skip lesions

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18
Q

75% of Central Osteosarcomas are in

A

metaphyses of long bones

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19
Q

Central Osteosarcomas are m/c at the
•
•

A

distal end of femur

and Proximal tibia and humerus

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20
Q

what usually acts as barrier to spread?

A

Physis

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21
Q
  • Focal lesion in metaphysis
  • Mottled, permeative lesion
  • Poorly defined zone of transition
  • cortical distruption
A

Central Osteosarcoma

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22
Q

Dense ivory or sclerotic lesion filling medullary

space

A

Central Osteosarcoma

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23
Q

Spiculated or Sunburst periosteal reaction

in soft tissue and occasionally see Codman’s Triangles

Study These Flashcards
A

Central Osteosarcoma

24
Q

Ill-defined permeative mixed lytic/blastic lesion

can cross the growth plate

25
soft tissue mass and spiculated periosteal reaction indicates
rapid growth
26
seen with large sclerotic | lesions
Cumulous cloud formation
27
Large soft tissue mass formation that may contain
ossification
28
Amputation if accessible and there is no... | Radiotherapy for local pain control
metastasis
29
Average time between recognition of pulmonary | disease and death is
6 months
30
Lytic presentation is rapidly
fatal
31
radiograph of osteosarcoma of distal femoral shaft
- aggressive periosteal changes - Codman triangles - soft tissue mass
32
Sagittal T1-weighted MRI osteosarcoma
``` - abnormal signal intensity is present throughout the visible shaft and metaphysis - growth plate has limited extension of the tumor - Cortical destruction ```
33
Radiograph of femur with osteosarcoma shows | a typical
Codman triangle
34
Mixed sclerotic/lytic primary bone | lesion at the metaphysis with pathological fracture
central Osteosarcoma
35
- Cystic expansile lesion of the distal metadiaphysis that abuts the epiphyseal plate - intermediate signal on T1, and high on T2 images
central Osteosarcoma
36
Rare, Independent lesions occuring simultaneously
Multicentric Osteosarcoma
37
Multicentric Osteosarcoma occur in what age group?
5-10
38
- primary lesions with Rapidly fatal course - blastic lesions which increase alkaline phosphatase - Pulmonary metastasis occurs early
Multicentric Osteosarcoma
39
- Multiple blastic lesions - Bilateral and fairly symmetric - Metaphyseal
Multicentric | Osteosarcoma
40
Slow growing well-differentiated osteosarcoma located on bone surface in juxtacortical location within periosteum in 30-50 yo
Parosteal Osteosarcoma
41
50% of Parosteal Osteosarcomas occur where?
posterior surface of distal femur
42
Average size of Parosteal Osteosarcoma
10 cm
43
- Lobulated, sessile, bony mass with broad based attachment to bone - Cleavage plane = 1-3mm
Parosteal Osteosarcoma
44
helpful imaging for Parosteal Osteosarcoma?
CT
45
DDx for Parosteal Osteosarcoma
Myositis Ossificans Traumatica (MOT)
46
Parosteal Osteosarcoma | vs Myositis Ossificans Traumatica (MOT)
Sarcomas are denser centrally grows over time (exact opposite for MOT)
47
Malignant degeneration of benign disorders to osteosarcoma
Secondary Osteosarcoma
48
who is susceptible to Secondary Osteosarcomas
Watch Dial Painters Ingested radium | (10-15 years later)
49
Secondary Osteosarcoma looks like osteosarcoma with the
Permeative, motheaten, periosteal rxn, soft tissue mass
50
In 1926, _____ was considered a | miracle elixir
radium
51
avg latent period for Post-radiation Sarcoma
15
52
used for Angiography in 1950’s
Thorotrast Injection
53
Large soft tissue mass not adjacent to bone that m/c affects the thigh in 30-50 yo
Extraosseous Osteosarcoma
54
Common pulmonary metastasis in
Extraosseous Osteosarcoma
55
Non-contrast CT of the chest showing multiple, subcentimeter, calcified pulmonary nodules consistent with
metastatic Paget’s sarcoma

Tri 6 - Tumors (12 decks)

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