7. Hematologic Disorders

Question 1

Chronic, congenital, and hereditary hemolytic anemia almost exclusive in black individuals with episodic abdominal crises, jaundice, bone pain and dactylitis

Answer 1

Sickle Cell Anemia

Question 2

Sickle Cell Anemia patients have a predisposition to

Answer 2

Salmonella osteomyelitis

Question 3

Vascular compromise in sickle Cell Anemia results in

Answer 3

“H” or “fish” vertebra

Question 4

Ischemia of the central endplate from

Answer 4

sickling crisis

Question 5

bilateral hip pain showing bilateral
femoral head infarcts and osteonecrosis with subchondral collapse
of the superior femoral articular surface

Answer 5

Sickle Cell Anemia

Question 6

Painful swellings of the hands and feet common in infancy, aggravated by cold weather.

Answer 6

Sickle Cell Dactylitis

Question 7

Sickle Cell Dactylitis

Answer 7

Hand-Foot Syndrome

Question 8

Individuals with sickle cell disease are predisposed

to _______ secondary to ischemic injury of both bone and GI tract

Answer 8

osteomyelitis

Question 9

periostitis and osteopenia on radiograph

Answer 9

Osteomyelitis

Question 10

The most sensitive study for sickle cell anemai is a

Answer 10

T1 fat saturation

study performed post gadolinium contrast

Question 11

In SCA there will be ischemic changes to the ________ in

8-20% of patients

Answer 11

Femoral Head

Question 12

Repeated episodes of splenic infarction causes the spleen to decrease in size

Answer 12

Autosplenectomy (from sickle cell)

Question 13

Lytic processes are present at the metacarpals, along

with periostitis

Answer 13

Advanced Dactylitis from Sickle Cell Anemia

Question 14

• H vertebra
• dactylitis
• splenomegaly
• hair on end
• osteonecrosis
• bone infarct
• osteomyelitis
• ## bone deformity

Answer 14

sickle cell anemia

Question 15

Hereditary disorder of hemoglobin synthesis

Answer 15

Thalassemia

Cooley’s anemia, Mediterranean anemia

Question 16

Retarded growth in thalassemia is due to

Answer 16

severe anemia

Question 17

Hepatosplenomegaly in thalassemia is due to

Answer 17

severe hemolytic anemia

Question 18

Mongoloid facies in thalassemia is due to

Answer 18

ineffective erythropoiesis and marrow hyperplasia

Question 19

Maxillary overgrowth also called

Answer 19

rodent facies

Question 20

• Expansion of medullary space
• Thinning of the cortices
• Expansion of bone diameter (Erlenmeyer Flask Deformity)
• Osteoporosis
• Resorption of fine trabeculae with thickening of the
  remaining trabeculae
• Honeycomb trabeculae

Answer 20

Radiographic Findings of Thalassemia due to marrow hyperplasia

Question 21

Erlenmeyer flask deformity and Premature fusion of growth plates

Answer 21

Thalassemia Growth Disturbances

Question 22

In thalassemia the hyperplasia of bone

marrow results in

Answer 22

cortical thinning, loss of tubulation, and coarse trabeculae

Question 23

Thalassemia

The radiating spicules of bone (“Hair-On-End) is due to

Answer 23

erythroid hyperplasia

Question 24

Coarsened trabecular
pattern (honeycomb) and
Osteoporosis with
thinning of the cortices

Answer 24

Thalassemia

Question 25

squaring of the | metacarpals

Answer 25

Thalassemia

Question 26

``` Lobulated soft tissue opacities are noted overlying the ribs anteriorly and posteriorly ```

Answer 26

Extramedullary | Hematopoiesis in Thalassemia

Question 27

two MC bleeding disorders with skeletal abnormalities which are both sex linked recessive

Answer 27

1. Classic Hemophilia (hemophilia A) | 2. Christmas Disease (hemophilia B)

Question 28

Females are carriers for Hemophilia gene but manifested | only in

Answer 28

males

Question 29

Intraosseous Hemorrhage in Hemophilia leads to

Answer 29

hemophilic arthropathy

Question 30

Hemophilic Arthropathy Resembles

Answer 30

``` Neurotrophic Arthropathy (Charcot Joint) ```

Question 31

Repeated intraarticular bleeding and dense joint effusion from hemosiderin which increases density of soft tissues surrounding joint

Answer 31

Hemophilic Arthropathy

Question 32

Intraosseous hemorrhage may result | in expansile lesions simulating neoplasm

Answer 32

Hemophilic | Pseudotumor

Question 33

malignant disease of marrow with proliferating WBCs

Answer 33

Leukemia

Question 34

MC childhood malignancy

Answer 34

Acute leukemia

Question 35

- Osteopenia - Radiolucent submetaphyseal bands - Bone destruction - Periostitis

Answer 35

leukemia

Question 36

Lucent metaphyseal band in a child who complained of pain in the legs

Answer 36

Leukemic Lines