4 - STRUCTURE AND FUNCTIONS OF SYSTEMS Flashcards

1
Q

what are the (4) main types of tissue?

A

epithelial (skin or internal organ covering)

connective (bone, cartilage, blood)

nervous

muscle

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2
Q

differentiate between negative and positive feedback

A

negative feedback: bringing conditions back to their normal or homeostatic function

positive feedback: an action that intensifies a condition so that it is driven further beyond its normal limits (e.g., labor contraction, lactation, or sexual orgasm)

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3
Q

how many lobes are in your right and left lung?

A

right lung: 3 lobes

left lung: 2 lobes

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4
Q

what is the membrane surrounding the lungs called? what are it’s 2 layers called?

A

pluerae, a membranous cover

inner layer: visceral pleura
- lines the lungs

outer layer: parietal pleura
- lines the chest cavity aka thoracic cavity

in between is the interpleural space

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5
Q

what is the diaphragm? what role does the diaphragm play?

A

a muscle that’s the lower border of the thoracic cavity. separates the thoracic cavity from the abdominal cavity

when you inhale, the diaphragm flats, allowing your chest cavity/lungs to expand

when you exhale, the diaphragm relaxes and pushes back upward which causes your chest and lungs to shrink in size, forcing air outward

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6
Q

what type of cell lines the respiratory tract? what do they do? where are these cells found?

A

respiratory epithelium

they produce mucus to moisten and protect our airways

the cells also have cilia which sweep away trapped pathogens and particles

found everywhere in the respiratory tract except the pharynx and larynx

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7
Q

list the structures of the respiratory tract in order

A

mouth/nose

pharynx

larynx

trachea

bronchi

bronchiole

alveoli

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8
Q

in the nose/mouth, what cell secretes mucus?

A

goblet cells (part of the respiratory epithelium)

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9
Q

what role does the pharynx play?

A

serves as the passageway for air and food (to the respiratory system and the digestive system)

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10
Q

what happens if a piece of food gets stuck in your windpipe?

A

the larynx will trigger the cough reflex to clear your airways

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11
Q

describe the structure of the trachea

A

a tube lined with c-shaped cartilage rings

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12
Q

what’s the epiglottis?

A

a structure covering the trachea, preventing solids/liquids from accidentally entering. when we breathe air, the epiglottis remains open so air can pass thru

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13
Q

what are alveoli? describe them

A

where gas exchange occurs between the respiratory and circulatory system

small, grape-like clusters

have a thin layer of cells, surrounded by capillaries. this layer serves as the interface between the respiratory system and the circulatory system

coated with surfactant, a liquid covering that reduces the surface tension, preventing H2O from collapsing the alveoli

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14
Q

what role does surfactant play in the respiratory system?

A

is a coating the covers alveoli, preventing it from collapsing as we inhale and exhale

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15
Q

what are the (2) major functions of the respiratory system?

A

internal respiration

external respiration

(both work together to get oxygen from the outside environment into our body’s cells and CO2 out our blood and exhaled)

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16
Q

differentiate between internal and external respiration

A

external respiration
- entry of air into lungs
- gas exchange between alveoli and blood (CO2 from blood to lungs to be exhaled; O2 from lungs to blood) – supplies blood with oxygen

internal respiration
- gas exchange between blood and cells (CO2 from cells to blood to be taken away to lungs; O2 from blood to cells) – supplies cells with oxygen
- intracellular respiration processes

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17
Q

how does gas exchange between the alveoli and the capillaries occur (in the respiratory system)

A

via simple diffusion (no transport proteins needed!!): gases like oxygen and carbon dioxide can simply diffuse across the thin alveoli membrane

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18
Q

how does CO2 move in the bloodstream? (how’s it transported?)

A

considered bulk flow!!: volumes of fluid move from an area of higher pressure in a capillary bed to an area of lower pressure in the tissues via filtration

primarily transported in the plasma, the liquid portion of blood in the form of bicarbonate (HCO3-)

most CO2 in the blood gets combined with water to form carbonic acid which then dissolved into bicarbonate and H+ ions. this reaction is catalyzed by enzyme, carbonic anhydrase. it occurs in red blood cells

can also be transported as it is (CO2). it can mix directly with the plasma as a gas or can bind with hemoglobin inside of the RBCs, forming carbaminohemoglobin

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19
Q

how does oxygen move in the bloodstream? (how’s it transported?)

A

primarily transported in the blood via hemoglobin

this is considered bulk flow: volumes of fluid move from an area of higher pressure in a capillary bed to an area of lower pressure in the tissues via filtration.

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20
Q

how do gases in the blood get to the cells of our body?

A

oxygen will be unloaded by the hemoglobin and diffuse out of the red blood cells across the thin walls of our blood vessels thru any interstitial fluid, finally entering the cell by diffusing across their membrane

CO2 follows the opposite path. it diffuses out of the cell, across the membrane, thru the interstitial fluids, and across the blood vessel walls where they can be transported by red blood cells as bicarbonate

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21
Q

what part of the brain controls respiration? what does it do specifically and how?

A

medulla oblongata

makes sure you’re always breathing, whether it’s conscious or unconscious

will also adjust breathing rate depending on oxygen needs of the body. this is done thru chemoreceptors which monitor levels of certain chemicals in the blood. the medulla specifically looks for H+ ions in the bloodstream. this is because when CO2 is transported in the blood, the process produced H+ ions. so when there’s lots of CO2, there will be lots of H+ ions. the medulla will signal the diaphragm contract so oxygen can be brought in and then CO2 exhaled.

some chemoreceptors also looks at concentrations of oxygen and CO2

an increase in H+ or CO2 will cause an increase in breathing rate. High blood oxygen partial pressure would cause a decrease in breathing rate.

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22
Q

how are fish able to survive and get oxygen without being exposed directly to air?

A

gills are highly folded surfaces that provide a large surface area across which gas exchange can occur

to get oxygen from the water, fish use something called countercurrent exchange. as a fish swims thru water, water flows over the gills in the opposite direction of the blood that is flowing thru the fish. as the water and blood flow past one another, the oxygen that is dissolved in the water, diffuses into the bloodstream, replenishing the oxygen levels in the fish’s blood

this process occurs many times due to the large surface area which is how fish are able to survive from the oxygen gained from the countercurrent exchange

countercurrent exchange maximizes diffusion of oxygen into the blood and carbon dioxide into water

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23
Q

why do fish die when they’re taken out of water?

A

water helps keep their gills separated, maintaining the large surface area

when removed from the water, their gills collapse onto one another, reducing the surface area. leads to death due to insufficient oxygen intake

** FISH DO NOT HAVE LUNGS!!

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24
Q

describe hemoglobin

A

a protein that functions to transport oxygen in our bloodstream

has 4 polypeptide subunits. each of these subunits contain an Iron (Fe) atom which is critical to the function as Iron is what binds to the oxygen

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25
describe cooperativity in hemoglobins
in cooperativity, a molecule has multiple binding sites. when oxygen binds to one site, it increases the affinity for the next oxygen to bind. so, each oxygen that binds makes it easier for the next one to bind note that hemoglobin can bind up to 4 oxygens (1 for each iron atom) --- the reverse is true as well! when you remove an oxygen from hemoglobin, it becomes easier for the next oxygen to come off
26
what is myoglobin?
used to transport oxygen to and from the cell in muscles equivalent of hemoglobin has a different binding affinity from hemoglobin
27
describe the structure of hemoglobin
has 4 heme groups: each with an iron atom in the centre surrounded by a porphyrin ring. the iron is able to form up to 6 bonds, one of which is to the oxygen note that heme is a prosthetic group (a non protein, iron, attached to a protein)
28
what does it mean when the oxygen-hemoglobin association curve has been shifted to the right?
leads to reduced affinity between oxygen and the hemoglobin. hemoglobin will release oxygen more easily -- due to increased oxygen demands, the hemoglobin will be less stingy! so, a left shift means increased affinity. hemoglobin will hold onto oxygen more tightly. this is when cells have less oxygen need
29
what (5) factors causes the oxygen-hemoglobin association curve to shift right? describe these factors
"CADET - face right", an increase in the following will cause the curve to shift right CO2: an increase in CO2 = an increase in cellular respiration = oxygen being used up and supply needs to be replenished Acid: increased CO2 levels = more acid = hemoglobin is more likely to release oxygen due to conformational change induced by increased acidity (acidic = low pH). this conformational change will preferentially bind to CO2 2,3 DPG: a metabolite that gets consumed whenever oxygen is present. but if oxygen isn't present, 2,3 DPG builds up so it's presence indicates lack of oxygen in tissue Exercise: it consumes oxygen and produces CO2 during its process Temperature: high temp = high metabolic rate = consuming more oxygen and cells will demand more of it than usual
30
define thermoregulation
control of exchange of heat with the environment
31
differentiate between ectotherms and endotherms
ectotherms (COLD-BLOODED) - obtain body heat from the environment - include invertebrates, amphibians, reptiles, and fish endotherms (WARM-BLOODED) - generate their own body heat and have a much higher basal metabolic rate (BMR) than ectotherms
32
what are cnidaria?
includes soft-bodied stinging animals such as corals, sea anemones, and jellyfish
33
how does respiration work in cnidaria?
direct with the environment!! have large surface areas and every cell is either exposed to the environment or close to it → simple diffusion of gases directly with outside environment (flatworms and some small animals also exhibit this type of respiration)
34
what are annelids?
include earthworms, polychaete worms, and leeches members of the group are to some extent segmented, in other words, made up of segments that are formed by subdivisions that partially transect the body cavity
35
how does respiration work in annelids?
mucus secreted by earthworms provides a moist surface for gaseous exchange via diffusion the circulatory system brings oxygen to cells, and waste products back to the skin for excretion
36
what are arthropods?
includes such familiar forms as lobsters, crabs, spiders, mites, insects, centipedes, and millipedes. distinguishing feature of arthropods is the presence of a jointed skeletal covering composed of chitin (a complex sugar) bound to protein
37
how does respiration work in arthropods?
series of chitin-lined respiratory tubules called trachea that open to the surface via openings called spiracles, through which oxygen enters and carbon dioxide exits oxygen carriers such as hemoglobin are not needed due to the direct distribution and removal of respiratory gases between the air and body cells the moistened tracheal endings ease the rate of diffusion DIFFERENT FOR SPIDERS: they have book lungs that are stacks of flattened membranes enclosed in internal chambers
38
describe the structure of lungs
these are invaginated structures made of two sub-portions: the left lung and right lung the left lung is smaller and consists of 2 lobes, while the right lung is made of 3 lobes left lung is smaller to accommodate the heart, which is also on the left side of the chest lungs have a membranous cover known as the pleurae, which have two pleura layers: the visceral and parietal pleura. the space in between these two layers is the intrapleural space
39
describe the pressure in the intrapleural space (space between the two membranes of the lung) and lungs as we inhale
has negative (lower) pressure relative to the atmosphere. if stabbed, air rushes in and causes the lung to collapse the pressure of this intrapleural space decreases as we inhale: as the diaphragm contracts, the lung cavity opens up, and this increase in volume equates to a decrease in pressure similarly, the pressure inside of the lungs also changes. as we inhale, the volume of the lungs as expands as the diaphragm drops. by doing so, we create a negative pressure relative to the atmosphere, causing air to rush in considered bulk flow!!: the lungs increase in volume and decrease in pressure, leading to a bulk flow of air into lungs
40
describe the haldane effect?
it describes how the deoxygenation of blood increases its ability to carry CO2 when hemoglobin is saturated with oxygen, its capability to hold CO2 is reduced. essentially, we pick up CO2 in the tissues where it’s generated, and get rid of it at the lungs and exchange it for oxygen. hemoglobin without oxygen acts as a blood buffer by accepting H+ → this reduced hemoglobin has a higher capacity to form carbaminohemoglobin, rather than the oxygen carrying kind, explaining how the Haldane Effect occurs. in summary, the Haldane Effect relates how [O2] is affecting hemoglobin’s affinity for CO2 and H+
41
describe the bohr effect
when tissues are high in CO2, and therefore high in H+, tissues are not getting a lot of oxygen, and we want to oxygenate them as a result, the hemoglobin once near the tissues is exposed to the higher CO2 and H+ levels, and changes its structure to the reduced form. this reduced form now releases its O2 to the deoxygenated tissues, and preferentially binds to CO2. at the lungs, the CO2 wants out and is released. the H+ concentration is also lower here due to bicarbonate being converted back into CO2 for release. at this point, hemoglobin will change back to its non-reduced state that preferentially binds to oxygen, which holds it more tightly under these conditions. the Bohr Effect, therefore, relates to how CO2 and H+ affect hemoglobin’s affinity for O2. ---- hemoglobin binding affinity decreases under conditions of low pH (high CO2/high H+) which leads to oxygen loads released by hemoglobin since both oxygen and H+ compete for hemoglobin binding sites
42
what is emphysema?
a disease marked by destruction of the alveoli
43
what effects does smoking have on the respiratory system?
smoking can damage the cilia of respiratory cells and allow toxins to remain in the lungs mucus produced by goblet cells increases, and lungs have a decreased means of moving mucous out, leading to a persistent yet unproductive cough can lead to bronchitis, emphysema, and lung cancer
44
differentiate between respiratory acidosis and alkalosis
Respiratory Acidosis - results from inadequate ventilation; we don’t clear enough CO2 and it builds up, so more H+ is formed, lowering the pH Respiratory Alkalosis - results from breathing too rapidly (hyperventilation); we are losing CO2 too quickly, so H+ and HCO3- start combining to form more CO2, and the pH begins rising
45
differentiate between metabolic and respiratory acidosis/alkalosis
important to understand that metabolic acidosis and alkalosis are not due to breathing issues - you may alter breathing to compensate, but the cause is not breathing related.
46
differentiate between the fetal and adult oxygen-hemoglobin dissociation curve
fetal hemoglobin curve is shifted left of the adult hemoglobin curve because the structure has a higher binding affinity in order to grab O2 from maternal blood
47
differentiate between the oxygen dissociation curve of myoglobin and hemoglobin
myoglobin of muscle has a hyperbolic curve since the structure doesn’t participate in allosteric cooperative binding due to the single subunit shape myoglobin also saturates quickly and releases in situations of very low oxygen “emergency situations”
48
what has a greater affinity for hemoglobin than oxygen?
carbon monoxide (CO) has a 200x greater affinity for hemoglobin than oxygen does [forms carboxyhemoglobin] and requires administration of pure oxygen to displace it once bound
49
differentiate between respiration in mammals and birds (avian)
due to the unique anatomy of birds, respiration is both continuous and unidirectional air sacs allow birds to exchange gas during both inhalation and exhalation — oxygen rich incoming air is first stored in air sacs before entering lungs for exhalation, so it is not mixed with the deoxygenated outgoing air ---- In mammalian respiration there is tidal breathing — we breathe in and out through the same tubing, inhibiting gas exchange during exhalation. Deoxygenated air is mixed with some fresh air during inhalation, thus some of it is re-inhaled. Much less efficient than birds.
50
what is tidal volume? (Vᴛ)
the volume of air that is normally inhaled or exhaled in one quiet breath
51
what is inspiratory reserve volume (IRV)?
the maximum volume of air that can be inhaled after a normal tidal volume inhalation
52
what is expiratory reserve volume (ERV)?
the maximum volume of air that can be exhaled after a normal tidal volume exhalation
53
what is residual volume (RV)?
the amount of air remaining in the lungs after maximum exhalation air that cannot be exhaled
54
what is vital capacity (VC)?
the maximum volume of air that can be exhaled after a maximum inspiration expressed as IRV + VT + ERV
55
what is inspiratory capacity (IC)?
the volume of air that can be inhaled after a normal exhalation expressed as VT + IRV
56
what is functional residual capacity (FRC)?
the volume of air remaining in the lungs after normal exhalation expressed as ERV + RV
57
what is total lung capacity (TLC)?
the maximum amount of air that the lungs can accommodate expressed as IC + FRC
58
Give the sequence that correctly describes the order of valves that blood passes through as it flows through the heart?
Tricuspid valve → Pulmonary valve → Mitral valve → Aortic valve
59
what is pericardium? describe it
a double layered sac that envelopes the heart the outer layer: fibrous pericardium - protects the heart and holds it in place the inner layer: serous pericardium - consists of 2 layers with space in between: parietal, pericardial cavity, visceral - space (pericardial cavity) is filled with fluid that lubricates the heart as it pumps, preventing friction between the layers
60
what are the (4) chambers of the heart? where are they in relation to each other?
right atrium / left atrium right ventricle / left ventricle atriums on top ventricles below
61
what separates the 4 chambers of the heart?
upper and lower chambers are separated by valves the right and left sides are separated by the septum, a muscular wall
62
which chambers carry oxygenated blood and which carry deoxygenated blood? what does this mean?
the right side carries deoxygenated blood which needs to be oxygenated SO they get pumped to the lungs the left side carries oxygenated blood (fresh from the lungs) which is needed by tissues of the body
63
describe the pressures experienced by the blood in the different chambers of the heart? why do they differ?
the blood in the atria (upper chambers) experiences low pressures as they just need to be pumped to the ventricles (lower chambers) the blood in the ventricles experiences much higher pressure as they need to be pumped to different organs and tissues in the body
64
why do ventricles of the heart have thicker walls than the atria?
the blood in the ventricles experiences much higher pressure as they need to be pumped to different organs and tissues in the body - hence, thicker walls to pump the blood with more force
65
what is the purpose of valves in the heart?
to prevent the backflow of blood the valves only open under pressure and then close
66
what are the (4) valves in the heart? where are they?
tricuspid: between the right atrium and right ventricle pulmonary: between right ventricle and pulmonary arteries mitral (bicuspid): between the left atrium and left ventricle aortic: between the left ventricle and aorta
67
differentiate between arteries and veins
veins carry blood to heart (deoxygenated) arteries carry blood away from the heart (oxygenated) the pulmonary circuit is an exception - pulmonary veins carry oxygenated blood - pulmonary arteries carry deoxygenated blood
68
what is the aorta?
a really thick muscular artery that distributes blood from the left ventricle to the rest of the body really strong: can withstand high pressure of blood pumped from the heart
69
how many heart chambers do fish have?
2 heart chambers: 1 atrium and 1 ventricle
70
how many heart chambers do amphibians have?
3 heart chambers: 2 atria and 1 ventricle
71
how many heart chambers do reptiles have?
3 heart chambers: 2 atria and 1 ventricle
72
how many heart chambers do birds have?
4 chambers: 2 atria and 2 ventricles
73
what's the exception to the heart chamber rule for reptiles?
normally, reptiles have 3 heart chambers (2 atria and 1 ventricle) BUT alligators and crocodiles have 4 heart chambers
74
what are the (2) pathways of the circulatory system?
pulmonary: blood pumped to and from lungs systemic: blood pumped to and from tissues of the body
75
what are the steps of pulmonary circulation?
blood is pumped from the right ventricle - thru the pulmonary valve - to the pulmonary arteries blood gets reoxygenated at the capillaries/alveoli of the lungs where gas exchange occurs blood travels back to the heart's left atrium via pulmonary veins
76
where in the body does blood have the lowest oxygen concentration?
pulmonary artery blood has been depleted of all its nutrients and oxygen by the rest of the body by the time it has reached the pulmonary artery
77
where in the body does blood have the highest oxygen concentration?
pulmonary vein blood was just supplied with fresh oxygen from the lungs
78
what are the steps of systemic circulation?
left atria contracts and pushes blood thru the mitral valve to left ventricle left ventricle contracts (very strong) and blood travels thru the aortic valve to aorta blood from aorta travels to entire body blood reaches the capillaries (capillary beds) in the tissues of the body. the cells surrounding the capillaries absorb the nutrients and oxygen from the arterial end and unload carbon dioxide and waste into the venous end of the capillaries veins carry the blood back to the superior and inferior vena cava which empty it into the right atrium blood from the right atrium goes thru the tricuspid valve into the right ventricle
79
what are the (2) phases to heart contraction?
systole: when the heart contracts, squeezing out blood diastole: when the heart relaxes after a contraction
80
what starts a heart contraction? what initiated our heartbeat and how is that electrical signal spread?
a group of cells called the sinoatrial node (aka SA node aka pacemaker) which can generate their own electrical impulse they initiate our heartbeat by depolarizing and spreading an electrical signal. the electrical signal spreads smoothly from one cardiac muscle cell to another connecting these cardiac muscle cells at the intercalated discs are gap junctions which allow ions to flow smoothly from one cell to another - allows the electrical signal to move in a coordinated way ------ the electrical signal begins at the SA node. this electrical signal causes both of the atria to contract as it spreads thru out the walls of the atria the electrical signal arrives at the AV node (atrio ventricular node). there's a bit of delay to make sure the blood has been completely ejected from the atria to fill the ventricles. the electrical signal will travel from the AV node down thru cells called the Bundle of His (which is in the septum between the lower ventricles) when the electrical signal hits the bottom, it branches upwards and outwards thru the cell walls of the ventricles via Purkinje Fibers. this causes both ventricles to contract simultaneously
81
what are the (6) phases of the cardiac cycle mapped out on the electrocardiogram - the heartbeat monitor thingy?
P-wave: represents the electrical signal of the atria contracting. after the P-wave QRS-complex: big spike due to the ventricles contracting/depolarizing (which hides the atria repolarizing) after the QRS-complex T-wave: represents the ventricles repolarization to prepare for another contraction after the T-wave REFER TO DIAGRAMS
82
describe this relationship: cardiac output = stroke volume x heart rate
cardiac output: volume of blood that gets pushed out of the ventricles in 60 seconds stroke volume: volume of blood that gets pushed out of the ventricles per contraction heart rate: number of contractions your heart has per minute
83
describe this relationship: stroke volume = end diastolic volume - end systolic volume
the reason for this formula is because when ventricles contract, they don't push out 100% of the blood they hold ---- stroke volume: volume of blood that gets pushed out of the ventricles per contraction end diastolic volume: how much blood in the ventricle before the contraction end systolic volume: how much blood in the ventricle after the contraction
84
describe this relationship: blood pressure = cardiac output x systemic vascular resistance
blood pressure: pressure exerted by circulating blood onto the vessel walls cardiac output: volume of blood that gets pushed out of the ventricles in 60 seconds -- the more blood pushed out of the heart per minute, more pressure onto walls systemic vascular resistance: measure of resistance to flow of blood. influenced by diameter of blood vessels and blood viscosity
85
what factors influence systemic vascular resistance?
influenced by diameter of blood vessels and blood viscosity ---- systemic vascular resistance: measure of resistance to flow of blood
86
which type of blood vessel is the thickest and why?
arteries they must withstand the highest pressure to pump blood to the rest of the body
87
describe the pathway blood travels in terms of blood vessels
from the heart arteries arterioles capillaries (where gas exchange occurs) veinules veins
88
describe the composition of arteries (its layers)
FROM OUTERMOST TO INNER!!! connective tissue layer which strengthens the artery and allows it to attach to nearby tissue thick muscular layer of smooth muscle. it contracts/relaxes to regulate the diameter of the artery. also allows artery to withstand the high pressure of blood being pumped with a lot of force from the heart elastic layer. gives the artery flexibility to stretch and withstand the pressure of the blood layer of endothelium cells. allows the blood to flow easily TO SUMMARIZE, arteries are large, muscular, and elastic
89
describe the composition of arterioles (its layers)
connective tissue layer which strengthens the arteriole and allows it to attach to nearby tissue smooth muscle layer in between (thinner here than in the artery but for its proportion, arterioles have a thicker one... hence able to exert more control with diameter and blood pressure here) inner layer of endothelial cells. allows the blood to flow easily
90
describe the composition of capillaries (its layers)
ONLY ONE LAYER a single-celled layer of endothelium -- allows for oxygen and nutrients and waste to diffuse easily
91
what are the (2) types of blood pressure forces at work in the capillaries? describe them and how they work together
hydrostatic: pressure from the fluid inside the vessels pushing up against the blood vessel wall - wants to move things out of the capillaries oncotic: works in the opposite direction. pressure from the proteins in the blood attracting water from outside the vessel. it pulls things like extra fluids, waste product, and CO2. hydrostatic pressure and oncotic is present in every part of a blood vessel. but the amount of each varies. in the arterial side of the capillaries, hydrostatic pressure is high = net filtration of fluids and small molecules get pushed out into the tissue space note that oncotic pressure stays the same in the venous end, hydrostatic pressure is lower than oncotic = net movement back into the capillaries = reabsorption
92
what are precapillary sphincters?
rings of muscle that contract to clamp down and block blood vessels or relax to let blood flow more easily can control where blood goes. this selective blood flow is helpful to stop blood for going to certain tissues depending on body's needs
93
describe the composition of veinules (its layers)
outer layer of thin connective tissue thin muscle layer in the middle endothelium layer on the inside
94
describe the composition of vein (its layers)
connective tissue outer layer muscle layer (thin because pressure is very low here) elastic layer inner endothelium layer
95
how do veins make sure blood reaches the heart considering the low pressure it has?
one way valves that prevent back flow backwards due to gravity also assisted by skeletal muscle contractions to propel the blood forward blood will eventually reach the superior and inferior vena cava
96